ArticleMolecular and cellular biology2005
Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Iron and Cell Death.Advances in experimental medicine and biology · 2025Review
- Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications.Cell death & disease · 2024Review
- Scabertopin Derived fromCancers · 2022Article
- Double-edge sword roles of iron in driving energy production versus instigating ferroptosis.Cell death & disease · 2022Review
- The role of iron homeostasis and iron-mediated ROS in cancer.American journal of cancer research · 2021Review
- Artesunate induces ER-derived-ROS-mediated cell death by disrupting labile iron pool and iron redistribution in hepatocellular carcinoma cells.American journal of cancer research · 2021Article
- Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis.Environmental science and pollution research international · 2020Review
- Iron and Cancer.Annual review of nutrition · 2018Review
- Article
- Coupling heme and iron metabolism via ferritin H chain.Antioxidants & redox signaling · 2014Review
- The Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation.Cell research · 2014Article
- H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice.Frontiers in pharmacology · 2014Article
- Article
- The role of iron and reactive oxygen species in cell death.Nature chemical biology · 2014Review
- Vasculotoxic and Proinflammatory Effects of Plasma Heme: Cell Signaling and Cytoprotective Responses.ISRN oxidative medicine · 2013Article
- Alternative ferritin mRNA translation via internal initiation.RNA (New York, N.Y.) · 2012Article
- Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases.Frontiers in pharmacology · 2012Article
- Programmed necrosis, not apoptosis, in the heart.Circulation research · 2011Review
- Molecular mechanisms of necroptosis: an ordered cellular explosion.Nature reviews. Molecular cell biology · 2010Review
- Tumor necrosis factor-mediated cell death: to break or to burst, that's the question.Cellular and molecular life sciences : CMLS · 2010Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Tumor necrosis factor (TNF) alpha is a cytokine capable of inducing caspase-dependent (apoptotic) cell death in some cells and caspase-independent (necrosis-like) cell death in others. Here, using a mutagenesis screen for genes critical in TNF-induced death in L929 cells, we have found that H-ferritin deficiency is responsible for TNF resistance in a mutant line and that, upon treatment with TNF, this line fails to elevate levels of labile iron pool (LIP), critical for TNF-induced reactive oxygen species (ROS) production and ROS-dependent cell death. Since we found that TNF-induced LIP in L929 cells is primarily furnished by intracellular storage iron, the lesser induction of LIP in H-ferritin-deficient cells results from a reduction of intracellular iron storage caused by less H-ferritin. Different from some other cell lines, the H-ferritin gene in L929 cells is not TNF inducible; however, when H-ferritin is expressed in L929 cells under a TNF-inducible system, the TNF-induced LIP and subsequent ROS production and cell death were all prevented. Thus, LIP is a common denominator of ferritin both in the enhancement of cell death by basal steady-state H-ferritin and in protection against cell death by induced H-ferritin, thereby acting as a key determinant of TNF-induced cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.