ArticleMolecular and cellular biology2005
Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes.Nature metabolism · 2026Article
- Hominini-specific regulation of the cell cycle by stop codon readthrough of FEM1B.Journal of cell science · 2024Article
- A recurrent missense variant in the E3 ubiquitin ligase substrate recognition subunit FEM1B causes a rare syndromic neurodevelopmental disorder.Genetics in medicine : official journal of the American College of Medical Genetics · 2024Article
- Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis.Nature communications · 2023Article
- gBLUP-GWAS identifies candidate genes, signaling pathways, and putative functional polymorphisms for age at puberty in gilts.Journal of animal science · 2023Article
- The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad.BMC medical genomics · 2021Article
- Article
- Atlas on substrate recognition subunits of CRL2 E3 ligases.Oncotarget · 2016Review
- The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions.Cell division · 2016Review
- Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1.Biochemical and biophysical research communications · 2013Article
- Proteomic profiles of mesenchymal stem cells induced by a liver differentiation protocol.International journal of molecular sciences · 2010Article
- Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress.Oncogene · 2009Article
- Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease.Genome biology · 2009Article
- FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome.Human reproduction (Oxford, England) · 2008Article
- Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation.The Journal of biological chemistry · 2008Article
- The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.EMBO reports · 2007Article
- Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels.BMC medical genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus is a disorder of glucose homeostasis involving complex gene and environmental interactions that are incompletely understood. Mammalian homologs of nematode sex determination genes have recently been implicated in glucose homeostasis and type 2 diabetes mellitus. These are the Hedgehog receptor Patched and Calpain-10, which have homology to the nematode tra-2 and tra-3 sex determination genes, respectively. Here, we have developed Fem1b knockout (Fem1b-KO) mice, with targeted inactivation of Fem1b, a homolog of the nematode fem-1 sex determination gene. We show that the Fem1b-KO mice display abnormal glucose tolerance and that this is due predominantly to defective glucose-stimulated insulin secretion. Arginine-stimulated insulin secretion is also affected. The Fem1b gene is expressed in pancreatic islets, within both beta cells and non-beta cells, and is highly expressed in INS-1E cells, a pancreatic beta-cell line. In conclusion, these data implicate Fem1b in pancreatic islet function and insulin secretion, strengthening evidence that a genetic pathway homologous to nematode sex determination may be involved in glucose homeostasis and suggesting novel genes and processes as potential candidates in the pathogenesis of diabetes mellitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.