ArticleMolecular and cellular biology2005
Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Identifying a novelWorld journal of clinical cases · 2025Article
- The Drosophila histone variant H2Av facilitates Notch signaling activity in a two-tier regulatory fashion.Cell communication and signaling : CCS · 2025Article
- The NuA4/TIP60 histone-modifying complex and Hr78 modulate theOpen life sciences · 2025Article
- SRCAP is involved in porcine reproductive and respiratory syndrome virus activated Notch signaling pathway.Journal of virology · 2024Article
- The Histone Chaperone Network Is Highly Conserved inInternational journal of molecular sciences · 2023Article
- LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP).Bioengineered · 2022Article
- The ATPase SRCAP is associated with the mitotic apparatus, uncovering novel molecular aspects of Floating-Harbor syndrome.BMC biology · 2021Article
- The Aedes aegypti Domino Ortholog p400 Regulates Antiviral Exogenous Small Interfering RNA Pathway Activity andmSphere · 2020Article
- Hepatocellular Carcinoma Mechanisms Associated with Chronic HCV Infection and the Impact of Direct-Acting Antiviral Treatment.Journal of hepatocellular carcinoma · 2020Review
- The True Story ofFrontiers in physiology · 2019Review
- Oncogenic Signaling Induced by HCV Infection.Viruses · 2018Review
- Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response.Nucleic acids research · 2018Article
- Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity inThe EMBO journal · 2018Article
- TheG3 (Bethesda, Md.) · 2018Article
- Protecting and Diversifying the Germline.Genetics · 2018Review
- Merge and separation of NuA4 and SWR1 complexes control cell fate plasticity inCell discovery · 2018Article
- The defining DNA methylation signature of Floating-Harbor Syndrome.Scientific reports · 2016Article
- Histone exchange, chromatin structure and the regulation of transcription.Nature reviews. Molecular cell biology · 2015Review
- Drosophila domino Exhibits Genetic Interactions with a Wide Spectrum of Chromatin Protein-Encoding Loci.PloS one · 2015Article
- Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.Nature genetics · 2014Article
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Authors and funding
3 authors.
Funding
Abstract
The putative ATPase chromatin-remodeling machine SRCAP was identified in a yeast two-hybrid protein screen by interaction with the histone acetylase CBP. SRCAP is implicated in the transcriptional coactivation of cyclic AMP- and steroid-dependent promoters, but no natural chromosomal targets for SRCAP regulation have been identified. DOM is the unique SRCAP homolog in Drosophila melanogaster. The goal of this study was to test whether SRCAP is a functional homolog of DOM and to identify potential activities and targets of SRCAP in vivo. We show that human SRCAP complements recessive domino mutant phenotypes. This rescue depends on an intact ATPase homology domain. SRCAP colocalizes extensively with DOM on Drosophila polytene chromosomes and is recruited to sites of active transcription, such as steroid-regulated loci, but not to activated heat shock loci. We show that SRCAP recruits Drosophila CBP to ectopic chromosomal sites, providing the first evidence to suggest that SRCAP and CBP interact directly or indirectly on chromosomes. We show that DOM is a Notch pathway activator in Drosophila and that wild-type SRCAP-but not an ATPase domain mutant-can substitute for DOM in Notch-dependent wing development. We show that SRCAP potentiates Notch-dependent gene activation in HeLa cells. Taken together, these data implicate SRCAP and DOM in developmental gene activation.
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