ArticleThe Plant cell2005
The evolutionarily conserved TOUGH protein is required for proper development of Arabidopsis thaliana.
Article in The Plant cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Next-Generation Mapping of the ACINUS-Mediated Alternative Splicing Machinery and Its Regulation by O-glycosylation inbioRxiv : the preprint server for biology · 2025Article
- Integrating GWAS with a gene co-expression network better prioritizes candidate genes associated with root metaxylem phenes in maize.The plant genome · 2024Article
- N4-acetylation of cytidine in mRNA plays essential roles in plants.The Plant cell · 2023Article
- Acidic and Alkaline Conditions Affect the Growth of Tree Peony Plants via Altering Photosynthetic Characteristics, Limiting Nutrient Assimilation, and Impairing ROS Balance.International journal of molecular sciences · 2022Article
- Regulation of pri-MIRNA processing: mechanistic insights into the miRNA homeostasis in plant.Plant cell reports · 2021Review
- Molecular Evolution and Diversification of Proteins Involved in miRNA Maturation Pathway.Plants (Basel, Switzerland) · 2020Article
- The 'how' and 'where' of plant microRNAs.The New phytologist · 2017Review
- The dicer-like1 homolog fuzzy tassel is required for the regulation of meristem determinacy in the inflorescence and vegetative growth in maize.The Plant cell · 2014Article
- Biogenesis, turnover, and mode of action of plant microRNAs.The Plant cell · 2013Review
- Catalog of Erycina pusilla miRNA and categorization of reproductive phase-related miRNAs and their target gene families.Plant molecular biology · 2013Article
- Post-transcriptional control of miRNA abundance in Arabidopsis.Plant signaling & behavior · 2012Review
- Regulation of miRNA abundance by RNA binding protein TOUGH in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- microRNA biogenesis and turnover in plants.Cold Spring Harbor symposia on quantitative biology · 2012Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we characterize the evolutionarily conserved TOUGH (TGH) protein as a novel regulator required for Arabidopsis thaliana development. We initially identified TGH as a yeast two-hybrid system interactor of the transcription initiation factor TATA-box binding protein 2. TGH has apparent orthologs in all eukaryotic model organisms with the exception of the budding yeast Saccharomyces cerevisiae. TGH contains domains with strong similarity to G-patch and SWAP domains, protein domains that are characteristic of RNA binding and processing proteins. Furthermore, TGH colocalizes with the splicing regulator SRp34 to subnuclear particles. We therefore propose that TGH plays a role in RNA binding or processing. Arabidopsis tgh mutants display developmental defects, including reduced plant height, polycotyly, and reduced vascularization. We found TGH expression to be increased in the amp1-1 mutant, which is similar to tgh mutants with respect to polycotyly and defects in vascular development. Interestingly, we observed a strong genetic interaction between TGH and AMP1 in that tgh-1 amp1-1 double mutants are extremely dwarfed and severely affected in plant development in general and vascular development in particular when compared with the single mutants.
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