Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2005
Treatment for depression and its relationship to improvement in quality of life and psychological well-being in multiple sclerosis patients.
Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of the impact of therapeutic education programs on the quality of life of people with Multiple Sclerosis.Health promotion perspectives · 2024Pooled it
- Understanding lifestyle self-management regimens that improve the life quality of people living with multiple sclerosis: a systematic review and meta-analysis.Health and quality of life outcomes · 2022Pooled it
- Pooled it
- Trajectories of change in well-being during cognitive behavioral therapies for anxiety disorders: Quantifying the impact and covariation with improvements in anxiety.Psychotherapy (Chicago, Ill.) · 2020Trial
- A mindfulness-based program for improving quality of life among hematopoietic stem cell transplantation survivors: feasibility and preliminary findings.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Trial
- The effect of telephone-administered cognitive-behavioral therapy on quality of life among patients with multiple sclerosis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2011Trial
- MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial.Neurology · 2010Trial
- Profile of depression in adolescents with inflammatory bowel disease: implications for treatment.Inflammatory bowel diseases · 2009Trial
- Relationships among depressive symptoms, benefit-finding, optimism, and positive affect in multiple sclerosis patients after psychotherapy for depression.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2008Trial
- Multiple Sclerosis Nursing to Improve Care and Education (MSNICE): an observational study.BMC nursing · 2025Article
- The Potential of Transcranial Direct Current Stimulation (tDCS) in Improving Quality of Life in Patients with Multiple Sclerosis: A Review and Discussion of Mechanisms of Action.Journal of clinical medicine · 2025Review
- Contributions of Eudaimonic Well-Being to Mental Health Practice.Mental health and social inclusion · 2023Article
- Greater mastery is associated with lower depression risk in a large international cohort of people with multiple sclerosis over 2.5 years.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Quality of life in individuals newly diagnosed with multiple sclerosis or clinically isolated syndrome.Journal of neurology · 2022Article
- The Big Five Personality Traits and Positive Orientation in Polish Adults with Multiple Sclerosis: The Role of Meaning in Life.International journal of environmental research and public health · 2022Article
- Interferons and Multiple Sclerosis: Lessons from 25 Years of Clinical and Real-World Experience with Intramuscular Interferon Beta-1a (Avonex).CNS drugs · 2021Review
- Explaining the facilitators of quality of life in patients with multiple sclerosis: a qualitative study.BMC neurology · 2021Article
- Improving Health of People With Multiple Sclerosis From a Multicenter Randomized Controlled Study in Parallel Groups: Preliminary Results on the Efficacy of a Mindfulness Intervention and Intention Implementation Associated With a Physical Activity Program.Frontiers in psychology · 2021Article
- Psychiatric disorders in multiple sclerosis.Journal of neurology · 2021Review
- Depression Comorbid With Stroke, Traumatic Brain Injury, Parkinson's Disease, and Multiple Sclerosis: Diagnosis and Treatment.Focus (American Psychiatric Publishing) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Depression, a common problem in multiple sclerosis (MS), is generally associated with poorer quality of life (QOL). However, it is unclear whether treating depression also extends to better perceived QOL. Understanding QOL in MS has been limited by narrow definitions and exclusive focus on symptomology, with little emphasis on positive aspects of QOL. This study examined the impact of treating depression on QOL in 60 patients with a relapsing form of MS and moderate to severe depression, who were randomly assigned to one of three validated 16-week treatments for depression: individual cognitive-behavioral therapy, group psychotherapy, or sertraline. QOL was measured by the MSQOL-54, a version of the SF-36 adapted for MS, and Ryff's scales of psychological well-being, which measure positive attitudes and functioning. Depression and QOL were measured at baseline and immediately following treatment completion. Controlling for baseline neurological impairment and baseline QOL scores, regression analyses showed treating depression was significantly associated with improvements in the MSQOL-54 scales (R2s = 0.19-0.55, p < 0.001) and in four of the six scales of psychological well-being: environmental mastery (R2 = 0.13, p < 0.001), positive relations (R2 = 0.08, p < 0.001), purpose in life (R2 = 0.16, p < 0.001), and self-acceptance (R2 = 0.26, p < 0.001). Findings suggest treating depression influences both the negative and positive aspects of QOL and underscore the importance of examining QOL with two complementary approaches.
Indexed as
Identifiers
16022063What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.