Evidence map›Paper›PMID 16021861›Full record

ArticleJournal of assisted reproduction and genetics2005

The reproductive performance of women with hypogonadotropic hypogonadism in an in vitro fertilization and embryo transfer program.

Ulun Ulug, Izhar Ben-Shlomo, Süleyman Tosun, Halit Firat Erden, Mehmet Ali Akman, Mustafa Bahceci

Open access · bronzeAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ulun UlugBahceci Women Health Care Center and German Hospital, Istanbul, Turkey.
Izhar Ben-Shlomo
Süleyman Tosun
Halit Firat Erden
Mehmet Ali Akman
Mustafa Bahceci
Taksim German Hospital · TRStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the outcome of women with hypogonadotropic hypogonadism undergoing in-vitro fertilization (IVF).

methodsWe retrospectively assessed outcomes in 58 women with hypogonadotropic hypogonadism (HH) and, as matched controls, in 116 women with tubal factor (TF) infertility who underwent assisted reproduction treatment (ART). For ovulation induction, human menopausal gonadotropin (hMG) was used in HH patients and a combination of hMG and gonadotropin releasing hormone (GnRH) agonist was used in TF patients. Conception and implantation rates, as well as duration of stimulation and number of oocytes retrieved, were the main outcome measures.

resultsOf the 58 HH patients, 53 (91.3%) responded adequately to ovulation induction and underwent ET. A larger amount of gonadotropins and a longer duration of ovarian stimulation were needed in HH patients than in TF patients. The mean number of retrieved oocytes and implantation rates did not differ between the groups. In addition, there were no differences between the HH and TF groups in pregnancy (53.8 vs. 48.6%) and multiple pregnancy (63.4 vs. 48.4%) rates. In the HH group, the miscarriage rate was 3.4%, and none of these patients developed severe OHSS.

conclusionIVF in HH patients, in which there was a background of previous failed ovulation induction, was as successful as in women with TF infertility.

Indexed as

Fertilization in VitroPregnancy OutcomeAdultFemaleGonadotropinsHumansHypogonadismOvulation InductionPregnancyRetrospective StudiesGonadotropins

Identifiers

PMID16021861
PMCPMC3455285
OpenAlexW1992067481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.