Trial reportPsychopharmacology2005
Cholinergic enhancement of episodic memory in healthy young adults.
Trial report in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Responding to requests from adult patients for neuroenhancements: guidance of the Ethics, Law and Humanities Committee.Neurology · 2009Guideline
- Functional connectivity and cognitive changes after donepezil treatment in healthy participants.Psychopharmacology · 2021Trial
- Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.Human brain mapping · 2017Trial
- Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Trial
- Effect of cholinergic neurotransmission modulation on visual spatial paired associate learning in healthy human adults.Psychopharmacology · 2013Trial
- Donepezil improves episodic memory in young individuals vulnerable to the effects of sleep deprivation.Sleep · 2009Trial
- Errorless practice as a possible adjuvant to donepezil in Alzheimer's disease.Journal of the International Neuropsychological Society : JINS · 2009Trial
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Towards Enhancing Drug Development Methodology to Treat Cognitive Impairment Associated With Schizophrenia and Other Neuropsychiatric Conditions: Insights From 2 Decades of Clinical Trials.Schizophrenia bulletin · 2025Review
- Neuroenhancement: State of the Art and Future Perspectives.Clinical neuropsychiatry · 2021Article
- Prevalence and correlates of stimulant and depressant pharmacological cognitive enhancement among Norwegian students.Nordisk alkohol- & narkotikatidskrift : NAT · 2018Article
- Quality of life of irradiated brain tumor survivors treated with donepezil or placebo: Results of the WFU CCOP research base protocol 91105.Neuro-oncology practice · 2018Article
- 'Drugs That Make You Feel Bad'? Remorse-Based Mitigation and Neurointerventions.Criminal law and philosophy · 2017Article
- Neurocognitive challenges in brain tumor survivors: is there anything we can do?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Article
- Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment.Neuropharmacology · 2014Review
- Pharmacological cognitive enhancement-how neuroscientific research could advance ethical debate.Frontiers in systems neuroscience · 2014Article
- Drug therapy of post-stroke aphasia: a review of current evidence.Neuropsychology review · 2011Review
- Cognitive impairment in acquired brain injury: a predictor of rehabilitation outcomes and an opportunity for novel interventions.PM & R : the journal of injury, function, and rehabilitation · 2011Review
- Cholinergic enhancement augments magnitude and specificity of visual perceptual learning in healthy humans.Current biology : CB · 2010Article
- Phencyclidine withdrawal disrupts episodic-like memory in rats: reversal by donepezil but not clozapine.The international journal of neuropsychopharmacology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAcetylcholine esterase (AchE) inhibitors are known to remediate symptoms of Alzheimer's disease. However, only few systematic data exist on the effects of cholinergic treatment on cognitive functions in normal subjects.
objectiveThis study evaluated the effects of donepezil, an inhibitor of AchE, on cognitive performance in young and healthy subjects.
methodsWe used a randomised double-blind parallel group placebo-controlled repeated measures design to investigate changes of cognitive functions in a group of 30 young healthy male subjects (mean age 23.9 years+/-2.24 SD) upon application of donepezil or placebo for 30 days. Attentional and executive functions, visual and verbal short-term and working memory, semantic memory, as well as verbal and visual episodic memory were investigated using an extensive neuropsychological test battery.
resultsTime-by-group interactions demonstrated significant drug effects that were specific to episodic memory in both the verbal and visual domain. Additionally, donezepil significantly improved long-term visual episodic recall. In none of the other functions under investigation any significant treatment effects were observed.
conclusionGiven this specific drug effect and the well-known relevance of the hippocampal region for episodic memory, we conclude that this region appears to be the major target of cholinergic enhancement in healthy subjects due to long-term inhibition of AchE.
Indexed as
Identifiers
16021483What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.