ArticleHuman genetics2005
Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin.
Article in Human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Orexin, serotonin, and energy balance.WIREs mechanisms of disease · 2022Review
- Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.Endocrine reviews · 2019Review
- Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents.International journal of endocrinology · 2016Article
- The genetics of human obesity.Annals of the New York Academy of Sciences · 2013Review
- Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications.Molecular psychiatry · 2012Review
- Accounting for a quantitative trait locus for plasma triglyceride levels: utilization of variants in multiple genes.PloS one · 2012Article
- Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight.Neurogenetics · 2011Article
- Association study of MDR1 and 5-HT2C genetic polymorphisms and antipsychotic-induced metabolic disturbances in female patients with schizophrenia.The pharmacogenomics journal · 2011Article
- Role of 5-HT(2C) receptor gene variants in antipsychotic-induced weight gain.Pharmacogenomics and personalized medicine · 2011Article
- Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels.Physiological genomics · 2010Article
- Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene.The pharmacogenomics journal · 2009Article
- The genetic contribution to non-syndromic human obesity.Nature reviews. Genetics · 2009Review
- The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.The pharmacogenomics journal · 2007Article
- Medical sequencing at the extremes of human body mass.American journal of human genetics · 2007Article
- WEIGHT GAIN AND ANTIPSYCHOTICS. DATA FROM EUFEST STUDY.Acta endocrinologica (Bucharest, Romania : 2005)Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The occurrence of obesity, eating disorders, and related diseases has increased in many parts of the world. Given that few strong genetic factors have been found, it is clear that these are complex multi-factorial diseases. The serotonin receptor 2C, a member of the 5-HTergic system, has been implicated in the control of phagia and obesity. We report a detailed investigation of linkage disequilibrium (LD) within and between the HTR2C promoter and the flanking sequences around a commonly utilized marker in the second coding exon of HTR2C. We suggest that inconsistent associations between HTR2C and several phenotypes, including obesity, may be due to the LD pattern across the gene in which recombination and gene conversion have been influential. The nucleotide and haplotype distribution is consistent with that of the neutral mutation model. The number of haplotypes suggests demographic influences or over dominant selection that may have a function in HTR2C expression. Using the fine LD pattern, we describe a possible association with promoter haplotypes and diplotypes, including a GT microsatellite, and body mass index (BMI) > or =30 kgm(-2) (P<0.0001). SNP -995G>A heterozygotes, as well as promoter diplotypes, were found to marginally influence higher serum leptin corrected for percentage body fat (P=0.01), which might suggest that these subjects are leptin resistant. Our results complement previous studies of HTR2C in both mice and humans, and suggest the importance of genetic variation and elucidating the fine LD structure in uncovering the genetic factors of obesity.
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