ReviewEuropean radiology2005
Diffusion-weighted MR imaging in leukodystrophies.
Review in European radiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 112 citations in OpenAlex.
- Imaging features of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia: a case report.Neuroradiology · 2026Article
- Magnetic resonance imaging in leukodystrophies: characteristic patterns and diagnostic relevance.Arquivos de neuro-psiquiatria · 2026Review
- Diagnostic value of quantitative MR spectroscopy metabolite ratios for Canavan disease.Frontiers in radiology · 2026Article
- Hereditary spastic paraplegia and extensive leukoencephalopathy: a case report of a unique phenotype associated with a GJB1/Cx32 p.Pro174Ser variant.BMC neurology · 2024Article
- Vanishing white matter disease: imaging, clinical and molecular correlation in Brazilian families.Neuroradiology · 2024Article
- Clinical Significance of Diffusion Tensor Imaging in Metachromatic Leukodystrophy.Neuropediatrics · 2023Article
- EIF2B2 gene mutation causing early onset vanishing white matter disease: a case report.Italian journal of pediatrics · 2022Article
- Loes Score: Clinical and Radiological Profile of 22 Patients of X-Linked Adrenoleukodystrophy: Case Series from a Single Center.The Indian journal of radiology & imaging · 2021Article
- The neuroimaging findings of monocarboxylate transporter 1 deficiency.Neuroradiology · 2020Article
- Vanishing white matter disease with different faces.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Identifying patients with neuronal intranuclear inclusion disease in Singapore using characteristic diffusion-weighted MR images.Neuroradiology · 2019Article
- Vanishing white matter disease imaged over 3 years.SA journal of radiology · 2019Article
- Similarities and differences between infantile and early childhood onset vanishing white matter disease.Journal of neurology · 2018Article
- Brain MRI in a newborn with Zellweger syndrome: ADC quantitation in white matter disease.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Vanishing white matter: a leukodystrophy due to astrocytic dysfunction.Brain pathology (Zurich, Switzerland) · 2018Review
- Redefining the phenotype of ALSP andNeurology. Genetics · 2017Review
- Cockayne syndrome: a diffusion tensor imaging and volumetric study.The British journal of radiology · 2016Article
- Predominant Corticospinal Tract Involvement in a Late Infant with Krabbe Disease.Japanese clinical medicine · 2016Article
- Neurometabolic diseases of childhood.Pediatric radiology · 2015Review
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukodystrophies are genetically determined metabolic diseases, in which the underlying biochemical abnormality interferes with the normal build-up and/or maintenance of myelin, which leads to hypo- (or arrested) myelination, or dysmyelination with resultant demyelination. Although conventional magnetic resonance imaging has significantly contributed to recent progress in the diagnostic work-up of these diseases, diffusion-weighted imaging has the potential to further improve our understanding of underlying pathological processes and their dynamics through the assessment of normal and abnormal diffusion properties of cerebral white matter. Evaluation of conventional diffusion-weighted and ADC map images allows the detection of major diffusion abnormalities and the identification of various edema types, of which the so-called myelin edema is particularly relevant to leukodystrophies. Depending on the nature of histopathological changes, stage and progression gradient of diseases, various diffusion-weighted imaging patterns may be seen in leukodystrophies. Absent or low-grade myelin edema is found in mucopolysaccharidoses, GM gangliosidoses, Zellweger disease, adrenomyeloneuropathy, L-2-hydroxyglutaric aciduria, non-ketotic hyperglycinemia, classical phenylketonuria, Van der Knaap disease and the vanishing white matter, medium grade myelin edema in metachromatic leukodystrophy, X-linked adrenoleukodystrophy and HMG coenzyme lyase deficiency and high grade edema in Krabbe disease, Canavan disease, hyperhomocystinemias, maple syrup urine disease and leukodystrophy with brainstem and spinal cord involvement and high lactate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.