ArticleJournal of neurology2006
Seasonal fluctuation of multiple sclerosis births in Sardinia.
Article in Journal of neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Evaluation of Month of Birth in Neuromyelitis Optica Spectrum Disorders (NMSOD) and Multiple Sclerosis (MS).Multiple sclerosis international · 2021Article
- A nationwide survey of the influence of month of birth on the risk of developing multiple sclerosis in Sweden and Iceland.Journal of neurology · 2018Article
- Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases.The EPMA journal · 2017Review
- Month of birth and level of insolation as risk factors for multiple sclerosis in Poland.PloS one · 2017Article
- Confounding in association studies: month of birth and multiple sclerosis.Journal of neurology · 2014Review
- Confounding underlies the apparent month of birth effect in multiple sclerosis.Annals of neurology · 2013Article
- Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis.Therapeutic advances in neurological disorders · 2013Article
- [Vitamin D and multiple sclerosis : the role for risk of disease and treatment].Der Nervenarzt · 2013Review
- Can we prevent or treat multiple sclerosis by individualised vitamin D supply?The EPMA journal · 2013Article
- Month of birth, vitamin D and risk of immune-mediated disease: a case control study.BMC medicine · 2012Article
- Prenatal vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation.International journal of molecular sciences · 2012Article
- Influence of photoperiod on hormones, behavior, and immune function.Frontiers in neuroendocrinology · 2011Review
- Multiple sclerosis genetics--is the glass half full, or half empty?Nature reviews. Neurology · 2010Review
- Multiple sclerosis, vitamin D, and HLA-DRB1*15.Neurology · 2010Review
- Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis.The American journal of clinical nutrition · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Study results from different geographical areas provide some circumstantial evidence that, when compared with the general population, people who later in life develop multiple sclerosis (MS) have a pattern of birth excess numbers in spring and late summer, which may disclose an association with MS-predisposing environmental agents. To identify the presence of season-related cluster of MS birth in Sardinia we have designed a case-control study in the province of Sassari, Northern Sardinia, insular Italy, an area at very-high and increasing risk for MS. Mean birth incidence rate of people with MS (810 cases) on a three-and six-months basis were compared with that of two control populations: the MS unaffected siblings (1069), sharing genetic material with patients, and a representative number of births (247,612) of the general population of the study area. We found that the birth in months peaking in spring significantly represents one risk factor for future MS development. This seasonal deviation of MS births reveals an intriguing epidemiological overlap with common environmental agents, which may open a new scenario of hypothetical explanations for environmental factors perhaps affecting the CNS at the crucial time of myelination or shaping the newborn immune system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.