Efficacy of antidepressants in adults.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

64 citing papers in PubMed, 16 syntheses or guidelines pooled it.

1. Beneficial and harmful effects of tricyclic antidepressants for adults with major depressive disorder: a systematic review with meta-analysis and trial sequential analysis.BMJ mental health · 2024
   Pooled it
2. Efficacy, Safety, and Acceptability of Pharmacologic Treatments for Pediatric Migraine Prophylaxis: A Systematic Review and Network Meta-analysis.JAMA pediatrics · 2020
   Pooled it
3. Raising Placebo Efficacy in Antidepressant Trials Across Decades Explained by Small-Study Effects: A Meta-Reanalysis.Frontiers in psychiatry · 2020
   Pooled it
4. What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis.BMJ open · 2019
   Pooled it
5. Guidelines for the pharmacological acute treatment of major depression: conflicts with current evidence as demonstrated with the German S3-guidelines.BMC psychiatry · 2019
   Pooled it
6. Efficacy and Safety of Selective Serotonin Reuptake Inhibitors, Serotonin-Norepinephrine Reuptake Inhibitors, and Placebo for Common Psychiatric Disorders Among Children and Adolescents: A Systematic Review and Meta-analysis.JAMA psychiatry · 2017
   Pooled it
7. Adjunctive atypical antipsychotic treatment for major depressive disorder: a meta-analysis of depression, quality of life, and safety outcomes.PLoS medicine · 2013
   Pooled it
8. Depression in adults: drug and physical treatments.BMJ clinical evidence · 2011
   Pooled it
9. Efficacy of antidepressants and benzodiazepines in minor depression: systematic review and meta-analysis.The British journal of psychiatry : the journal of mental science · 2011
   Pooled it
10. Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011
    Pooled it
11. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder.Molecular psychiatry · 2010
    Pooled it
12. Escitalopram versus other antidepressive agents for depression.The Cochrane database of systematic reviews · 2009
    Pooled it
13. How effective are second-generation antipsychotic drugs? A meta-analysis of placebo-controlled trials.Molecular psychiatry · 2009
    Pooled it
14. Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2008
    Pooled it
15. Is there evidence for negative effects of antidepressants on suicidality in depressive patients? A systematic review.European archives of psychiatry and clinical neuroscience · 2006
    Pooled it
16. Dose-response relationship of duloxetine in placebo-controlled clinical trials in patients with major depressive disorder.Psychopharmacology · 2006
    Pooled it
17. Orbitofrontal cortex-hippocampus potentiation mediates relief for depression: A randomized double-blind trial and TMS-EEG study.Cell reports. Medicine · 2023
    Trial
18. Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Trial
19. The effectiveness of an online interdisciplinary intervention for mental health promotion: a randomized controlled trial.BMC psychology · 2021
    Trial
20. A randomised cross-over study assessing the "blue pyjama syndrome" in major depressive episode.Scientific reports · 2017
    Trial

4 more citing papers are in PubMed but not listed here.

Corrections and comments

• Commented on by
  Why stop at antidepressants?2005

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as