ArticleGenetics2005
Multiple signatures of positive selection downstream of notch on the X chromosome in Drosophila melanogaster.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Evaluating power to detect recurrent selective sweeps under increasingly realistic evolutionary null models.Evolution; international journal of organic evolution · 2023Article
- Evaluating power to detect recurrent selective sweeps under increasingly realistic evolutionary null models.bioRxiv : the preprint server for biology · 2023Article
- Enrichment of Hard Sweeps on the X Chromosome in Drosophila melanogaster.Molecular biology and evolution · 2023Article
- Population Genomics on the Fly: Recent Advances in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Background selection as null hypothesis in population genomics: insights and challenges fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Genetic hitchhiking versus background selection: the controversy and its implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Review
- On reconciling single and recurrent hitchhiking models.Genome biology and evolution · 2009Article
- Species-wide genetic variation and demographic history of Drosophila sechellia, a species lacking population structure.Genetics · 2009Article
- Estimation of fine-scale recombination intensity variation in the white-echinus interval of D. melanogaster.Journal of molecular evolution · 2009Article
- Tracking footprints of maize domestication and evidence for a massive selective sweep on chromosome 10.Proceedings of the National Academy of Sciences of the United States of America · 2009Review
- A genomic scan for selection reveals candidates for genes involved in the evolution of cultivated sunflower (Helianthus annuus).The Plant cell · 2008Article
- Selection in the making: a worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2.Genetics · 2008Article
- Hitchhiking mapping reveals a candidate genomic region for natural selection in three-spined stickleback chromosome VIII.Genetics · 2008Article
- Genomewide spatial correspondence between nonsynonymous divergence and neutral polymorphism reveals extensive adaptation in Drosophila.Genetics · 2007Article
- Article
- Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster.Genetics · 2007Article
- Selective sweeps reveal candidate genes for adaptation to drought and salt tolerance in common sunflower, Helianthus annuus.Genetics · 2007Article
- Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To identify genomic regions affected by the rapid fixation of beneficial mutations (selective sweeps), we performed a scan of microsatellite variability across the Notch locus region of Drosophila melanogaster. Nine microsatellites spanning 60 kb of the X chromosome were surveyed for variation in one African and three non-African populations of this species. The microsatellites identified an approximately 14-kb window for which we observed relatively low levels of variability and/or a skew in the frequency spectrum toward rare alleles, patterns predicted at regions linked to a selective sweep. DNA sequence polymorphism data were subsequently collected within this 14-kb region for three of the D. melanogaster populations. The sequence data strongly support the initial microsatellite findings; in the non-African populations there is evidence of a recent selective sweep downstream of the Notch locus near or within the open reading frames CG18508 and Fcp3C. In addition, we observe a significant McDonald-Kreitman test result suggesting too many amino acid fixations species wide, presumably due to positive selection, at the unannotated open reading frame CG18508. Thus, we observe within this small genomic region evidence for both recent (skew toward rare alleles in non-African populations) and recurring (amino acid evolution at CG18508) episodes of positive selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.