ArticleGenetics2005
The extent of linkage disequilibrium caused by selection on G6PD in humans.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 108 citations in OpenAlex.
- Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria.Malaria journal · 2012Trial
- Mapping anemia prevalence across Indonesia.Asia Pacific journal of clinical nutrition · 2025Article
- Spatial and temporal diversity of positive selection on shared haplotypes at the PSCA locus among worldwide human populations.Heredity · 2023Article
- Molecular dynamics of G6PD variants from sub-Saharan Africa.Biochemistry and biophysics reports · 2022Article
- G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19.The pharmacogenomics journal · 2021Article
- Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes.Molecular biology and evolution · 2021Article
- Functional genetic diversity in an exploited marine species and its relevance to fisheries management.Proceedings. Biological sciences · 2021Article
- Identifying adaptive alleles in the human genome: from selection mapping to functional validation.Human genetics · 2021Review
- Article
- Evidence of positively selected G6PD A- allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island.Molecular genetics & genomic medicine · 2020Article
- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020Review
- Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.eLife · 2017Article
- Computer simulation of human leukocyte antigen genes supports two main routes of colonization by human populations in East Asia.BMC evolutionary biology · 2015Article
- The Role of Standing Variation in Geographic Convergent Adaptation.The American naturalist · 2015Article
- Glucose-6-phosphate dehydrogenase deficiency among malaria patients of Honduras: a descriptive study of archival blood samples.Malaria journal · 2015Article
- Molecular Characterization of Bovine SMO Gene and Effects of Its Genetic Variations on Body Size Traits in Qinchuan Cattle (Bos taurus).International journal of molecular sciences · 2015Article
- Soft shoulders ahead: spurious signatures of soft and partial selective sweeps result from linked hard sweeps.Genetics · 2015Article
- Haplotype combination of the bovine PCSK1 gene sequence variants and association with growth traits in Jiaxian cattle.Journal of genetics · 2014Article
- Detecting selection using time-series data of allele frequencies with multiple independent reference Loci.G3 (Bethesda, Md.) · 2013Article
- Inferring selection intensity and allele age from multilocus haplotype structure.G3 (Bethesda, Md.) · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gene coding for glucose-6-phosphate dehydrogenase (G6PD) is subject to positive selection by malaria in some human populations. The G6PD A- allele, which is common in sub-Saharan Africa, is associated with deficient enzyme activity and protection from severe malaria. To delimit the impact of selection on patterns of linkage disequilibrium (LD) and nucleotide diversity, we resequenced 5.1 kb at G6PD and approximately 2-3 kb at each of eight loci in a 2.5-Mb region roughly centered on G6PD in a diverse sub-Saharan African panel of 51 unrelated men (including 20 G6PD A-, 11 G6PD A+, and 20 G6PD B chromosomes). The signature of selection is evident in the absence of genetic variation at G6PD and at three neighboring loci within 0.9 Mb from G6PD among all individuals bearing G6PD A- alleles. A genomic region of approximately 1.6 Mb around G6PD was characterized by long-range LD associated with the A- alleles. These patterns of nucleotide variability and LD suggest that G6PD A- is younger than previous age estimates and has increased in frequency in sub-Saharan Africa due to strong selection (0.1 < s < 0.2). These results also show that selection can lead to nonrandom associations among SNPs over great physical and genetic distances, even in African populations.
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