ArticleGenetics2005
Highly efficient sex chromosome interchanges produced by I-CreI expression in Drosophila.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Acentric chromosome congression and alignment on the metaphase plate via kinetochore-independent forces.Genetics · 2025Article
- Under the magnifying glass: The ups and downs of rDNA copy number.Seminars in cell & developmental biology · 2023Review
- Dynamic localization of DNA topoisomerase I and its functional relevance during Drosophila development.G3 (Bethesda, Md.) · 2021Article
- DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells.Nature communications · 2021Article
- Kinetochore-independent mechanisms of sister chromosome separation.PLoS genetics · 2021Article
- Micronuclei Formation Is Prevented by Aurora B-Mediated Exclusion of HP1a from Late-Segregating Chromatin inGenetics · 2018Article
- Enhancer of polycomb maintains germline activity and genome integrity in Drosophila testis.Cell death and differentiation · 2018Article
- Aurora B-mediated localized delays in nuclear envelope formation facilitate inclusion of late-segregating chromosome fragments.Molecular biology of the cell · 2015Article
- Transgenerational inheritance of diet-induced genome rearrangements in Drosophila.PLoS genetics · 2015Article
- Reduced rDNA copy number does not affect "competitive" chromosome pairing in XYY males of Drosophila melanogaster.G3 (Bethesda, Md.) · 2014Article
- Article
- A simple and rapid method for constructing ring-X chromosomes in Drosophila melanogaster.Chromosoma · 2011Article
- Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation.PLoS genetics · 2011Article
- Ribosomal DNA contributes to global chromatin regulation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Homing endonucleases catalyze double-stranded DNA breaks and somatic transgene excision in Aedes aegypti.Insect molecular biology · 2009Article
- Article
- Telomere loss provokes multiple pathways to apoptosis and produces genomic instability in Drosophila melanogaster.Genetics · 2008Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The homing endonuclease I-CreI recognizes a site in the gene encoding the 23S rRNA of Chlamydomonas reinhardtii. A very similar sequence is present in the 28S rRNA genes that are located on the X and Y chromosomes of Drosophila melanogaster. In this work we show that I-CreI expression in Drosophila is capable of causing induced DNA damage and eliciting cell cycle arrest. Expression also caused recombination between the X and Y chromosomes in the heterochromatic regions where the rDNA is located, presumably as a result of a high frequency of double-strand breaks in these regions. Approximately 20% of the offspring of males expressing I-CreI showed exceptional inheritance of X- and Y-linked markers, consistent with chromosome exchange at rDNA loci. Cytogenetic analysis confirmed the structures of many of these products. Exchange between the X and Y chromosomes can be induced in males and females to produce derivative-altered Y chromosomes, attached-XY, and attached-X chromosomes. This method has advantages over the traditional use of X rays for generating X-Y interchanges because it is very frequent and it generates predictable products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.