ArticleThe Journal of physiology2005
Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- KChIP1 splice variants modulate Kv4 channels by promoting P/C-type inactivation features.Scientific reports · 2026Article
- Unmasking subtype-dependent susceptibility to C-type inactivation in mammalian Kv1 channels.Biophysical journal · 2024Article
- Resurgent current in context: Insights from the structure and function of Na and K channels.Biophysical journal · 2024Review
- AFrontiers in pharmacology · 2022Article
- Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation.The Journal of general physiology · 2021Article
- High-Resolution Structures of KHandbook of experimental pharmacology · 2021Article
- KV1.2 channels inactivate through a mechanism similar to C-type inactivation.The Journal of general physiology · 2020Article
- The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels.Biophysical journal · 2020Article
- Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.PloS one · 2015Article
- The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation.Biophysical journal · 2014Article
- Role of outer-pore residue Y380 in U-type inactivation of KV2.1 channels.The Journal of membrane biology · 2013Article
- Voltage sensor inactivation in potassium channels.Frontiers in pharmacology · 2012Article
- Molecular determinants of U-type inactivation in Kv2.1 channels.Biophysical journal · 2011Article
- Mechanisms of closed-state inactivation in voltage-gated ion channels.The Journal of physiology · 2011Review
- Slow inactivation in Shaker K channels is delayed by intracellular tetraethylammonium.The Journal of general physiology · 2008Article
- VAMP2 interacts directly with the N terminus of Kv2.1 to enhance channel inactivation.Pflugers Archiv : European journal of physiology · 2008Article
- Modification of K+ channel-drug interactions by ancillary subunits.The Journal of physiology · 2008Review
- Mechanism of the modulation of Kv4:KChIP-1 channels by external K+.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
P/C-type inactivation of Kv channels is thought to involve conformational changes in the outer pore of the channel, culminating in a partial constriction of the selectivity filter. Recent studies have identified a number of phenotypic differences in the inactivation properties of different Kv channels, including different sensitivities to elevation of extracellular K+ concentration, and different state dependencies of inactivation. We have demonstrated that an alternatively spliced short form of Kv1.5, resulting in disruption of the T1 domain, exhibits a shift in the state dependence of inactivation in this channel, and in the current study we have examined this further to contrast the properties of inactivation from open versus closed states. In a TEA+-sensitive mutant of Kv1.5 (Kv1.5 R487T), 10 mM extracellular TEA+ inhibits inactivation in both full-length and T1-deleted channels, but does not inhibit closed-state inactivation in T1-deleted channel forms. Similarly, substitution of K+ and Na+ with Cs+ ions in the recording medium inhibits inactivation of both full-length and T1-deleted channel forms, but fails to inhibit closed-state inactivation of T1-deleted channels. Collectively, these data distinguish between open-state and closed-state inactivation, and suggest the presence of multiple possible mechanisms of inactivation coexisting in Kv1 channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.