ArticleMicrocirculation (New York, N.Y. : 1994)2005
Differential coronary microvascular exchange responses to adenosine: roles of receptor and microvessel subtypes.
Article in Microcirculation (New York, N.Y. : 1994), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Adenosine and adenosine receptor-mediated action in coronary microcirculation.Basic research in cardiology · 2021Review
- Sex differences influencing micro- and macrovascular endothelial phenotype in vitro.The Journal of physiology · 2018Article
- Local control of blood flow during active hyperaemia: what kinds of integration are important?The Journal of physiology · 2015Review
- Pre-exposure to adenosine, acting via A(2A) receptors on endothelial cells, alters the protein kinase A dependence of adenosine-induced dilation in skeletal muscle resistance arterioles.The Journal of physiology · 2014Article
- A1 adenosine receptor negatively modulates coronary reactive hyperemia via counteracting A2A-mediated H2O2 production and KATP opening in isolated mouse hearts.American journal of physiology. Heart and circulatory physiology · 2013Article
- Interactions between A(2A) adenosine receptors, hydrogen peroxide, and KATP channels in coronary reactive hyperemia.American journal of physiology. Heart and circulatory physiology · 2013Article
- Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine.The Journal of pharmacology and experimental therapeutics · 2010Article
- Cardiovascular sex differences influencing microvascular exchange.Cardiovascular research · 2010Review
- Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases.American journal of physiology. Heart and circulatory physiology · 2010Article
- Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome.Experimental biology and medicine (Maywood, N.J.) · 2009Article
- Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology.Handbook of experimental pharmacology · 2009Review
- Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling.American journal of physiology. Heart and circulatory physiology · 2008Article
- Adaptation of coronary microvascular exchange in arterioles and venules to exercise training and a role for sex in determining permeability responses.American journal of physiology. Heart and circulatory physiology · 2007Article
- Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability.American journal of physiology. Heart and circulatory physiology · 2006Article
- Endothelial focal adhesions and barrier function.The Journal of physiology · 2005Review
- Sexual dimorphism in the permeability response of coronary microvessels to adenosine.American journal of physiology. Heart and circulatory physiology · 2005Article
- Sex-Specific Characteristics of the Microcirculation.Advances in experimental medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess the role of adenosine receptors in the regulation of coronary microvascular permeability to porcine serum albumin (P(s)(PSA)).
methodsSolute flux was measured in single perfused arterioles and venules isolated from pig hearts using fluorescent dye-labeled probes by microspectro-fluorometry. Messenger RNA, protein, and cellular distribution of adenosine receptors in arterioles and venules were analyzed by RT-PCR, immunoblot, and immunofluorescence.
resultsControl venule P(s)(PSA) (10.7 +/- 4.8 x 10(- 7) cm x s(- 1)) was greater than that of arterioles (6.4+/- 2.8 x 10(-7) cm . s(-1); p < .05). Arteriolar P(s)(PSA) decreased (p < .05) with adenosine suffusion over the range from 10(- 8) to 10(-5) M, while venular P(s)(PSA) did not change. The nonselective A(1) and A(2) receptor antagonist, 8-(p-sulfophenyl) theophylline, blocked the adenosine-induced decrease in arteriolar P(s)(PSA). Messenger RNA for adenosine A(1), A(2A), A(2B), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells.
conclusionArteriolar P(s)(PSA) decreases with adenosine suffusion but not venular P(s)(PSA). Adenosine A(1), A(2A), and A(2B) receptors are expressed in both arterioles and venules. Selective receptor-linked cellular signaling mechanisms underlying the regulation of permeability remain to be determined.
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