ArticleThe Journal of clinical investigation1992
Magnesium relaxes arterial smooth muscle by decreasing intracellular Ca2+ without changing intracellular Mg2+.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Adjuncts to local anaesthetics in tonsillectomy: a systematic review and meta-analysis.Journal of anesthesia · 2017Pooled it
- Dietary magnesium intake and risk of metabolic syndrome: a meta-analysis.Diabetic medicine : a journal of the British Diabetic Association · 2014Pooled it
- Effect of orally administered magnesium on postoperative pain level and trismus after surgical removal of the lower third molars: a randomized, double-blind, placebo-controlled trial.Clinical oral investigations · 2020Trial
- Trial
- Dose-response relationship and time-course of the effect of inhaled magnesium sulphate on airflow in normal and asthmatic subjects.British journal of clinical pharmacology · 1995Trial
- Review
- Review
- Article
- Dietary supplements for treatment of endometriosis: A review.Acta bio-medica : Atenei Parmensis · 2022Review
- Magnesium intake is inversely associated with the risk of metabolic syndrome in the REasons for geographic and racial differences in stroke (REGARDS) cohort study.Clinical nutrition (Edinburgh, Scotland) · 2021Article
- Does Nutrition Affect Endometriosis?Geburtshilfe und Frauenheilkunde · 2021Article
- Gestational and Hormonal Effects on Magnesium Sulfate's Ability to Inhibit Mouse Uterine Contractility.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- The role of Mg2+ in immune cells.Immunologic research · 2013Review
- Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study.American journal of epidemiology · 2013Article
- New insights into myosin phosphorylation during cyclic nucleotide-mediated smooth muscle relaxation.Journal of muscle research and cell motility · 2012Article
- Brain lesions in newborns exposed to high-dose magnesium sulfate during preterm labor.Journal of perinatology : official journal of the California Perinatal Association · 2006Review
- Extracellular Mg(2+) blocks endothelin-1-induced contraction through the inhibition of non-selective cation channels in coronary smooth muscle.Pflugers Archiv : European journal of physiology · 2004Article
- Heat induced HSP20 phosphorylation without increased cyclic nucleotide levels in swine carotid media.BMC physiology · 2003Article
- cGMP-mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery.The Journal of physiology · 2000Article
- Magnesium sulfate in acute asthma.Indian journal of pediatrics · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Elevations in extracellular [Mg2+] ([Mg2+]o) relax vascular smooth muscle. We tested the hypothesis that elevated [Mg2+]o induces relaxation through reductions in myoplasmic [Ca2+] and myosin light chain phosphorylation without changing intracellular [Mg2+] ([Mg2+]i). Histamine stimulation of endothelium-free swine carotid medial tissues was associated with increases in both Fura 2- and aequorin-estimated myoplasmic [Ca2+], myosin phosphorylation, and force. Elevated [Mg2+]o decreased myoplasmic [Ca2+] and force to near resting values. However, elevated [Mg2+]o only transiently decreased myosin phosphorylation values: sustained [Mg2+]o-induced decreases in myoplasmic [Ca2+] and force were associated with inappropriately high myosin phosphorylation values. The elevated myosin phosphorylation during [Mg2+]o-induced relaxation was entirely on serine 19, the Ca2+/calmodulin-dependent myosin light chain kinase substrate. Myoplasmic [Mg2+] (estimated with Mag-Fura 2) did not significantly increase with elevated [Mg2+]o. These results are consistent with the hypothesis that increased [Mg2+]o induces relaxation by decreasing myoplasmic [Ca2+] without changing [Mg2+]i. These data also demonstrate dissociation of myosin phosphorylation from myoplasmic [Ca2+] and force during Mg(2+)-induced relaxation. This finding suggests the presence of a phosphorylation-independent (yet potentially Ca(2+)-dependent) mechanism for regulation of force in vascular smooth muscle.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.