ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2006
A multi-centre pilot proficiency programme to assess the quality of molecular detection of respiratory viruses.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Using the full spectral capacity (six channels) of a real-time PCR instrument can simplify diagnostic laboratory screening and typing protocols for pandemic H1N1 influenza.Influenza and other respiratory viruses · 2011Article
- Association between high nasopharyngeal viral load and disease severity in children with human metapneumovirus infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Article
- Role of respiratory pathogens in infants hospitalized for a first episode of wheezing and their impact on recurrences.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2008Article
- Impact of human bocavirus on children and their families.Journal of clinical microbiology · 2008Article
- Currently used nucleic acid amplification tests for the detection of viruses and atypicals in acute respiratory infections.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2007Review
- Nucleic acid amplification tests for detection of respiratory viruses.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2007Review
- Multiplexed reverse transcriptase PCR assay for identification of viral respiratory pathogens at the point of care.Journal of clinical microbiology · 2007Article
- Quality control of direct molecular diagnostics for methicillin-resistant Staphylococcus aureus.Journal of clinical microbiology · 2007Article
- Coronavirus HKU1 in an Italian pre-term infant with bronchiolitis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2007Article
- Impact of human coronavirus infections in otherwise healthy children who attended an emergency department.Journal of medical virology · 2006Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the quality of molecular detection of respiratory viruses in clinical diagnostic laboratories. STUDY
designRespiratory virus proficiency panels were produced from diluted stocks of respiratory viruses provided and tested by four reference laboratories. The panels consisted of strong positive, positive, low positive and negative samples for influenza viruses A and B, respiratory syncytial virus, parainfluenza viruses 1 and 3, adenovirus serotypes 4 and 7, human rhinovirus serotypes 16, 72 and 90, human coronaviruses OC43 and 229E. The panels were sent to 17 participants; results and information on methodology was collected.
resultsAll laboratories returned results, of which five submitted complete data sets. So, for analysis all results were combined. Samples were correctly identified by participants in 93.75%, 76.75% and 47.03% for the high positive, positive and low positive samples, respectively. One false positive was reported for all data sets (1.1%). The overall score for all assays using different methodologies was 78.8%. Laboratory performance was not dependant on methodology as all in-house methodologies could achieve optimal results, but dependant on careful optimisation and procedures specific to the laboratory.
conclusionsThe first proficiency panel showed that in general all participants performed well. Although, it also highlights areas for improvement for all participants in order to generate robust results for use in clinical diagnostics.
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