ArticleThe EMBO journal2005
TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.Cell death and differentiation · 2023Article
- Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4.Cell death & disease · 2021Article
- Targeted alternative splicing of TAF4: a new strategy for cell reprogramming.Scientific reports · 2016Article
- Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.Nature communications · 2016Article
- Diversity in TAF proteomics: consequences for cellular differentiation and migration.International journal of molecular sciences · 2014Review
- Article
- Targeting TBP-Associated Factors in Ovarian Cancer.Frontiers in oncology · 2014Review
- TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.PloS one · 2014Article
- Article
- A TAF4 coactivator function for E proteins that involves enhanced TFIID binding.Genes & development · 2013Article
- Article
- Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology.The Journal of biological chemistry · 2012Article
- The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells.Molecular and cellular biology · 2012Article
- Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.Nucleic acids research · 2012Article
- BzpF is a CREB-like transcription factor that regulates spore maturation and stability in Dictyostelium.Developmental biology · 2011Article
- CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.Nature reviews. Molecular cell biology · 2011Review
- Direct transactivator-transcription factor IID (TFIID) contacts drive yeast ribosomal protein gene transcription.The Journal of biological chemistry · 2010Article
- Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats.Functional & integrative genomics · 2010Article
- Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.The Journal of biological chemistry · 2010Article
- Promoting developmental transcription.Development (Cambridge, England) · 2010Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have inactivated transcription factor TFIID subunit TBP-associated factor 4 (TAF4) in mouse embryonic fibroblasts. Mutant taf4(-/-) cells are viable and contain intact TFIID comprising the related TAF4b showing that TAF4 is not an essential protein. TAF4 inactivation deregulates more than 1000 genes indicating that TFIID complexes containing TAF4 and TAF4b have distinct target gene specificities. However, taf4(-/-) cell lines have altered morphology and exhibit serum-independent autocrine growth correlated with the induced expression of several secreted mitotic factors and activators of the transforming growth factor beta signalling pathway. In addition to TAF4 inactivation, many of these genes can also be induced by overexpression of TAF4b. A competitive equilibrium between TAF4 and TAF4b therefore regulates expression of genes controlling cell proliferation. We have further identified a set of genes that are regulated both by TAF4 and upon adaptation to serum starvation and which may be important downstream mediators of serum-independent growth. Our study also shows that TAF4 is an essential cofactor for activation by the retinoic acid receptor and CREB, but not for Sp1 and the vitamin D3 receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.