Trial reportEuropean journal of clinical nutrition2005
Effects of prenatal multimicronutrient supplements on birth weight and perinatal mortality: a randomised, controlled trial in Guinea-Bissau.
Trial report in European journal of clinical nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 27 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Prenatal Multi-micronutrient Supplements on Pregnancy Outcome, Peri- and Neonatal Mortality on Maternal and Infant Nutritional Status: A Randomised, Controlled Trial Among Women in Guinea-Bissau
Efficacy of Lipid-based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants
Who cites it
71 citing papers in PubMed, 27 syntheses or guidelines pooled it.
- Impact of maternal micronutrient supplementation on pregnancy outcomes in developing countries: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Effect of different Iron-Folic acid (IFA) formulations, doses, and frequencies on pregnancy and neonatal outcomes compared to multiple micronutrients (MMN) among pregnant women: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Effects of vitamin and multiple micronutrient supplementation for pregnant and/or lactating women on maternal and infant nutritional status in low- and middle-income countries: a systematic review and meta-analysis.Advances in nutrition (Bethesda, Md.) · 2025Pooled it
- Contribution of Maternal Adherence to the Effect of Multiple Micronutrient Supplementation During Pregnancy: A Systematic Review and Individual Participant Data Meta-analysis.Advances in nutrition (Bethesda, Md.) · 2025Pooled it
- Effect of prenatal multiple micronutrient supplementation compared with iron and folic acid supplementation on size at birth and subsequent growth through 24 mo of age: a systematic review and meta-analysis.The American journal of clinical nutrition · 2025Pooled it
- Effects of prenatal small-quantity lipid-based nutrient supplements on pregnancy, birth, and infant outcomes: a systematic review and meta-analysis of individual participant data from randomized controlled trials in low- and middle-income countries.The American journal of clinical nutrition · 2024Pooled it
- Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- Antenatal multiple micronutrient supplements versus iron-folic acid supplements and birth outcomes: Analysis by gestational age assessment method.Maternal & child nutrition · 2023Pooled it
- Multiple-micronutrient supplementation in pregnant adolescents in low- and middle-income countries: a systematic review and a meta-analysis of individual participant data.Nutrition reviews · 2022Pooled it
- Pooled it
- Pooled it
- Nutritional interventions for preventing stunting in children (birth to 59 months) living in urban slums in low- and middle-income countries (LMIC).The Cochrane database of systematic reviews · 2019Pooled it
- Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019Pooled it
- Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2017Pooled it
- Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis.BMC medicine · 2016Pooled it
- Vitamin supplementation for preventing miscarriage.The Cochrane database of systematic reviews · 2016Pooled it
- Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2015Pooled it
- Intermittent oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2015Pooled it
- Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2015Pooled it
- Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2012Pooled it
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the effects of daily prenatal multimicronutrient supplementation on birth weight (BW) and perinatal mortality.
designRandomised, controlled, double masked trial.
settingUrban Guinea-Bissau, West Africa. SUBJECTS: A total of 2100 pregnant women (22+/-7 weeks pregnant at entry) were recruited through antenatal clinics, of which 1670 (79.5%) completed the trial. BW was available for 1100 live born babies.
interventionsIdentical-looking supplements containing one (MN-1) or two (MN-2) Recommended Dietary Allowances (RDA) of 15 micronutrients, or iron and folic acid (control).
resultsMean BW among 1100 live born infants was 3050+/-498 g with 11.9% being low birth weight (LBW, BW < 2500 g). Perinatal mortality was 82 per 1000 deliveries (N = 1670), and neonatal mortality 45 per 1000 live births (N = 1599). Mean BW in MN-1 (n = 360) and MN-2 (n = 374) groups were 53 [-19; 125] and 95 [24; 166] g higher than controls (n = 366). Proportion of LBW was 13.6% in control, and 12.0 and 10.1% in the MN-1 and MN-2 groups, respectively (P = 0.33). Among anaemic women (30%), MN-2 increased BW with 218 [81; 354] g compared to controls, with a decreased risk of LBW of 69 [27; 87]%. There were apparently no differences in perinatal mortality between groups.
conclusionsPrenatal micronutrient supplementation increased BW but did not reduce perinatal mortality in this study. Multimicronutrient supplementation with two RDA should be considered in future programmes to reduce the proportion of LBW.
Indexed as
Identifiers
16015266What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.