ArticleJournal of virology2005
High-potency human immunodeficiency virus vaccination leads to delayed and reduced CD8+ T-cell expansion but improved virus control.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Mechanistic basis of post-treatment control of SIV after anti-α4β7 antibody therapy.PLoS computational biology · 2021Article
- Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections.Frontiers in immunology · 2018Review
- Notwithstanding Circumstantial Alibis, Cytotoxic T Cells Can Be Major Killers of HIV-1-Infected Cells.Journal of virology · 2016Article
- Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Predicting the impact of CD8+ T cell polyfunctionality on HIV disease progression.Journal of virology · 2014Article
- Modeling the within-host dynamics of HIV infection.BMC biology · 2013Review
- Quantifying T lymphocyte turnover.Journal of theoretical biology · 2013Article
- CD8+ T cell control of HIV--a known unknown.PLoS pathogens · 2010Review
- Scaling aspects of lymphocyte trafficking.Journal of theoretical biology · 2009Review
- Estimating the impact of vaccination on acute simian-human immunodeficiency virus/simian immunodeficiency virus infections.Journal of virology · 2008Article
- The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection.Virology · 2008Article
- Kinetics of recombinant adenovirus type 5, vaccinia virus, modified vaccinia ankara virus, and DNA antigen expression in vivo and the induction of memory T-lymphocyte responses.Clinical and vaccine immunology : CVI · 2008Article
- Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut.Journal of virology · 2007Article
- Vaccine-induced T cells control reversion of AIDS virus immune escape mutants.Journal of virology · 2007Article
- Understanding the failure of CD8+ T-cell vaccination against simian/human immunodeficiency virus.Journal of virology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
CD8(+) T lymphocytes are thought to play an important role in the control of acute and chronic human immunodeficiency virus infections. However, there is a significant delay between infection and the first observed increase in virus-specific CD8(+) T-cell numbers. Prior to this time, viral kinetics are not significantly different between controls and vaccinees. Surprisingly, higher initial virus-specific CD8(+) T-cell numbers lead to a longer delay prior to initial CD8(+) T-cell expansion, and slower CD8(+) T-cell increases. Nevertheless, higher initial CD8(+) T-cell numbers were associated with reduced peak and chronic viral loads and reduced CD4(+) T-cell depletion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.