ArticleJournal of virology2005
A virus essential for insect host-parasite interactions encodes cystatins.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- The role of a viral symbiont in the thermal mismatch of host-parasitoid interactions.The Journal of experimental biology · 2026Article
- The caterpillar Manduca sexta brain shows changes in gene expression and protein abundance correlating with parasitic manipulation of behaviour.Scientific reports · 2024Article
- Cotesia congregata Bracovirus Circles EncodingJournal of virology · 2018Article
- Microbial inhibitors of cysteine proteases.Medical microbiology and immunology · 2016Review
- Functional annotation of Cotesia congregata bracovirus: identification of viral genes expressed in parasitized host immune tissues.Journal of virology · 2014Article
- Accidental genetic engineers: horizontal sequence transfer from parasitoid wasps to their Lepidopteran hosts.PloS one · 2014Article
- Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- When parasitic wasps hijacked viruses: genomic and functional evolution of polydnaviruses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Evolutionary mechanisms driving the evolution of a large polydnavirus gene family coding for protein tyrosine phosphatases.BMC evolutionary biology · 2012Article
- Retrovirus entry by endocytosis and cathepsin proteases.Advances in virology · 2012Article
- Paleozoic origin of insect large dsDNA viruses.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B.PloS one · 2011Article
- Article
- Parasitism of an insect Manduca sexta L. alters feeding behaviour and nutrient utilization to influence developmental success of a parasitoid.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Article
- Blurring borders: innate immunity with adaptive features.Clinical & developmental immunology · 2007Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cotesia congregata is a parasitoid wasp that injects its eggs in the host caterpillar Manduca sexta. In this host-parasite interaction, successful parasitism is ensured by a third partner: a bracovirus. The relationship between parasitic wasps and bracoviruses constitutes one of the few known mutualisms between viruses and eukaryotes. The C. congregata bracovirus (CcBV) is injected at the same time as the wasp eggs in the host hemolymph. Expression of viral genes alters the caterpillar's immune defense responses and developmental program, resulting in the creation of a favorable environment for the survival and emergence of adult parasitoid wasps. Here, we describe the characterization of a CcBV multigene family which is highly expressed during parasitism and which encodes three proteins with homology to members of the cystatin superfamily. Cystatins are tightly binding, reversible inhibitors of cysteine proteases. Other cysteine protease inhibitors have been described for lepidopteran viruses; however, this is the first description of the presence of cystatins in a viral genome. The expression and purification of a recombinant form of one of the CcBV cystatins, cystatin 1, revealed that this viral cystatin is functional having potent inhibitory activity towards the cysteine proteases papain, human cathepsins L and B and Sarcophaga cathepsin B in assays in vitro. CcBV cystatins are, therefore, likely to play a role in host caterpillar physiological deregulation by inhibiting host target proteases in the course of the host-parasite interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.