ArticleJournal of virology2005
Role of thymic output in regulating CD8 T-cell homeostasis during acute and chronic viral infection.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection.Virology · 2022Article
- Dynamics of thymus function and T cell receptor repertoire breadth in health and disease.Seminars in immunopathology · 2021Review
- Control of PersistentPathogens (Basel, Switzerland) · 2020Article
- Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Precursor exhausted T cells: key to successful immunotherapy?Nature reviews. Immunology · 2020Review
- When the Damage Is Done: Injury and Repair in Thymus Function.Frontiers in immunology · 2020Review
- Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy.Immunity & ageing : I & A · 2016Article
- Molecular and cellular insights into T cell exhaustion.Nature reviews. Immunology · 2015Review
- Infection of adult thymus with murine retrovirus induces virus-specific central tolerance that prevents functional memory CD8+ T cell differentiation.PLoS pathogens · 2014Article
- Tolerance has its limits: how the thymus copes with infection.Trends in immunology · 2013Review
- Quantifying T lymphocyte turnover.Journal of theoretical biology · 2013Article
- T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.Nature immunology · 2013Article
- γ-Herpesvirus reactivation differentially stimulates epitope-specific CD8 T cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Dissecting the requirements for maintenance of the CMV-specific memory T-cell pool.Viral immunology · 2011Article
- Post-thymic maturation: young T cells assert their individuality.Nature reviews. Immunology · 2011Review
- T cell exhaustion.Nature immunology · 2011Review
- Cutting edge: Virus-specific CD8+ T cell clones and the maintenance of replicative function during a persistent viral infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
- Role of PKR and Type I IFNs in viral control during primary and secondary infection.PLoS pathogens · 2010Article
- Functional glycosylation of dystroglycan is crucial for thymocyte development in the mouse.PloS one · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although it is well documented that CD8 T cells play a critical role in controlling chronic viral infections, the mechanisms underlying the regulation of CD8 T-cell responses are not well understood. Using the mouse model of an acute and chronic lymphocytic choriomeningitis virus (LCMV) infection, we have examined the relative importance of peripheral T cells and thymic emigrants in the elicitation and maintenance of CD8 T-cell responses. Virus-specific CD8 T-cell responses were compared between mice that were either sham thymectomized or thymectomized (Thx) at approximately 6 weeks of age. In an acute LCMV infection, thymic deficiency did not affect either the primary expansion of CD8 T cells or the proliferative renewal and maintenance of virus-specific lymphoid and nonlymphoid memory CD8 T cells. Following a chronic LCMV infection, in Thx mice, although the initial expansion of CD8 T cells was normal, the contraction phase of the CD8 T-cell response was exaggerated, which led to a transient but striking CD8 T-cell deficit on day 30 postinfection. However, the virus-specific CD8 T-cell response in Thx mice rebounded quickly and was maintained at normal levels thereafter, which indicated that the peripheral T-cell repertoire is quite robust and capable of sustaining an effective CD8 T-cell response in the absence of thymic output during a chronic LCMV infection. Taken together, these findings should further our understanding of the regulation of CD8 T-cell homeostasis in acute and chronic viral infections and might have implications in the development of immunotherapy.
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