ArticleJournal of virology2005
Identification of secret agent as the O-GlcNAc transferase that participates in Plum pox virus infection.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Host Factors GenesPlants (Basel, Switzerland) · 2023Article
- Phosphorylation of plant virus proteins: Analysis methods and biological functions.Frontiers in microbiology · 2022Review
- Novel nucleocytoplasmic protein O-fucosylation by SPINDLY regulates diverse developmental processes in plants.Current opinion in structural biology · 2021Review
- Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1.PLoS genetics · 2021Article
- Article
- Phosphorylation coexists with O-GlcNAcylation in a plant virus protein and influences viral infection.Molecular plant pathology · 2018Article
- A study of the structural properties of sites modified by the O-linked 6-N-acetylglucosamine transferase.PloS one · 2017Article
- A novel role of the potyviral helper component proteinase contributes to enhance the yield of viral particles.Journal of virology · 2014Article
- Plum pox virus and sharka: a model potyvirus and a major disease.Molecular plant pathology · 2014Review
- O-GlcNAc modification of the coat protein of the potyvirus Plum pox virus enhances viral infection.Virology · 2013Article
- Top 10 plant viruses in molecular plant pathology.Molecular plant pathology · 2011Review
- Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis.Amino acids · 2011Article
- Article
- Binding properties of the N-acetylglucosamine and high-mannose N-glycan PP2-A1 phloem lectin in Arabidopsis.Plant physiology · 2010Article
- O-GlcNAc protein modification in plants: Evolution and function.Biochimica et biophysica acta · 2010Review
- Functional analysis of HvSPY, a negative regulator of GA response, in barley aleurone cells and Arabidopsis.Planta · 2009Article
- Altered gene expression changes in Arabidopsis leaf tissues and protoplasts in response to Plum pox virus infection.BMC genomics · 2008Article
- Reciprocal phosphorylation and glycosylation recognition motifs control NCAPP1 interaction with pumpkin phloem proteins and their cell-to-cell movement.The Plant cell · 2007Article
- Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serine and threonine of many nuclear and cytoplasmic proteins are posttranslationally modified with O-linked N-acetylglucosamine (O-GlcNAc). This modification is made by O-linked N-acetylglucosamine transferases (OGTs). Genetic and biochemical data have demonstrated the existence of two OGTs of Arabidopsis thaliana, SECRET AGENT (SEC) and SPINDLY (SPY), with at least partly overlapping functions, but there is little information on their target proteins. The N terminus of the capsid protein (CP) of Plum pox virus (PPV) isolated from Nicotiana clevelandii is O-GlcNAc modified. We show here that O-GlcNAc modification of PPV CP also takes place in other plant hosts, N. benthamiana and Arabidopsis. PPV was able to infect the Arabidopsis OGT mutants sec-1, sec-2, and spy-3, but at early times of the infection, both rate of virus spread and accumulation were reduced in sec-1 and sec-2 relative to spy-3 and wild-type plants. By matrix-assisted laser desorption ionization-time of flight mass spectrometry, we determined that a 39-residue tryptic peptide from the N terminus of CP of PPV purified from the spy-3 mutant, but not sec-1 or sec-2, was O-GlcNAc modified, suggesting that SEC but not SPY modifies the capsid. While our results indicate that O-GlcNAc modification of PPV CP by SEC is not essential for infection, they show that the modification has a role(s) in the process.
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