ArticleJournal of neurophysiology2005
Properties of mouse spinal lamina I GABAergic interneurons.
Article in Journal of neurophysiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Intrinsic plasticity and birdsong learning.Neurobiology of learning and memory · 2021Review
- Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Co-expression of GAD67 and choline acetyltransferase in neurons in the mouse spinal cord: A focus on lamina X.Brain research · 2016Article
- Article
- Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Pain processing by spinal microcircuits: afferent combinatorics.Current opinion in neurobiology · 2012Article
- Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor-alpha.The Journal of physiology · 2011Article
- Article
- Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal horn.Journal of neurophysiology · 2011Article
- Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons.The Journal of physiology · 2010Article
- Compensation for variable intrinsic neuronal excitability by circuit-synaptic interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Synaptic pathways and inhibitory gates in the spinal cord dorsal horn.Annals of the New York Academy of Sciences · 2010Article
- Properties of GABAergic neurons in the rostral solitary tract nucleus in mice.Journal of neurophysiology · 2010Article
- NR2 subunits and NMDA receptors on lamina II inhibitory and excitatory interneurons of the mouse dorsal horn.Molecular pain · 2010Article
- Article
- Membrane capacitance measurements revisited: dependence of capacitance value on measurement method in nonisopotential neurons.Journal of neurophysiology · 2009Article
- Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn.Molecular pain · 2009Article
- Brain-derived neurotrophic factor drives the changes in excitatory synaptic transmission in the rat superficial dorsal horn that follow sciatic nerve injury.The Journal of physiology · 2009Article
- Low-threshold primary afferent drive onto GABAergic interneurons in the superficial dorsal horn of the mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Spinal cord injury causes plasticity in a subpopulation of lamina I GABAergic interneurons.Journal of neurophysiology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Lamina I is a sensory relay region containing projection cells and local interneurons involved in thermal and nociceptive signaling. These neurons differ in morphology, sensory response modality, and firing characteristics. We examined intrinsic properties of mouse lamina I GABAergic neurons expressing enhanced green fluorescent protein (EGFP). GABAergic neuron identity was confirmed by a high correspondence between GABA immunolabeling and EGFP fluorescence. Morphologies of these EGFP+/GABA+ cells were multipolar (65%), fusiform (31%), and pyramidal (4%). In whole cell recordings, cells fired a single spike (44%), tonically (35%), or an initial burst (21%) in response to current steps, representing a subset of reported lamina I firing properties. Membrane properties of tonic and initial burst cells were indistinguishable and these neurons may represent one functional population because, in individual neurons, their firing patterns could interconvert. Single spike cells were less excitable with lower membrane resistivity and higher rheobase. Most fusiform cells (64%) fired tonically while most multipolar cells (56%) fired single spikes. In summary, lamina I inhibitory interneurons are functionally divisible into at least two major groups both of which presumably function to limit excitatory transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.