ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Rat adrenal chromaffin cells are neonatal CO2 sensors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Hif-2α programs oxygen chemosensitivity in chromaffin cells.The Journal of clinical investigation · 2024Article
- Lactate sensing mechanisms in arterial chemoreceptor cells.Nature communications · 2021Article
- Striking parallels between carotid body glomus cell and adrenal chromaffin cell development.Developmental biology · 2018Article
- Hypoxia-regulated catecholamine secretion in chromaffin cells.Cell and tissue research · 2018Review
- Gene expression analyses reveal metabolic specifications in acute OThe Journal of physiology · 2017Article
- Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.American journal of physiology. Cell physiology · 2014Article
- Chronic exposure of neonatal rat adrenomedullary chromaffin cells to opioids in vitro blunts both hypoxia and hypercapnia chemosensitivity.The Journal of physiology · 2013Article
- Functional and transcriptional induction of aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α.PloS one · 2011Article
- Developmental and stress-induced remodeling of cell–cell communication in the adrenal medullary tissue.Cellular and molecular neurobiology · 2010Review
- The locus coeruleus and central chemosensitivity.Respiratory physiology & neurobiology · 2010Review
- Carotid body chemosensory responses in mice deficient of TASK channels.The Journal of general physiology · 2010Article
- Zebrafish (Danio rerio) gill neuroepithelial cells are sensitive chemoreceptors for environmental CO2.The Journal of physiology · 2010Article
- Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: role of alpha7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2alpha.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Developmental change of T-type Ca2+ channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia.The Journal of physiology · 2009Article
- Commentaries on Viewpoint: Central chemoreception is a complex system function that involves multiple brain stem sites.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Development of chemosensitivity in neurons from the nucleus tractus solitarii (NTS) of neonatal rats.Respiratory physiology & neurobiology · 2009Article
- Characterization of the chemosensitive response of individual solitary complex neurons from adult rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Developmental changes of chromaffin cell secretory response to hypoxia studied in thin adrenal slices.Pflugers Archiv : European journal of physiology · 2007Article
- Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress.The Journal of physiology · 2006Article
- Effect of carbon dioxide on calcitonin gene-related peptide secretion from trigeminal neurons.HeadacheArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the participation of adrenal medulla (AM) chromaffin cells in hypercapnic chemotransduction. Using amperometric recordings, we measured catecholamine (CAT) secretion from cells in AM slices of neonatal and adult rats perfused with solutions bubbled with different concentrations of CO2. The secretory activity augmented from 1.74 +/- 0.19 pC/min at 5% CO2 to 6.36 +/- 0.77 pC/min at 10% CO2. This response to CO2 was dose dependent and appeared without changes in extracellular pH, although it was paralleled by a drop in intracellular pH. Responsiveness to hypercapnia was higher in neonatal than in adult slices. The secretory response to hypercapnia required extracellular Ca2+ influx. Both the CO2-induced internal pH drop and increase in CAT secretion were markedly diminished by methazolamide (2 microm), a membrane-permeant carbonic anhydrase (CA) inhibitor. We detected the presence of two CA isoforms (CAI and CAII) in neonatal AM slices by in situ hybridization and real-time PCR. The expression of these enzymes decreased in adult AM together with the disappearance of responsiveness to CO2. In patch-clamped chromaffin cells, hypercapnia elicited a depolarizing receptor potential, which led to action potential firing, extracellular Ca2+ influx, and CAT secretion. This receptor potential (inhibited by methazolamide) was primarily attributable to activation of a resting cationic conductance. In addition, voltage-gated K+ current amplitude was also decreased by high CO2. The CO2-sensing properties of chromaffin cells may be of physiologic relevance, particularly for the adaptation of neonates to extrauterine life, before complete maturation of peripheral and central chemoreceptors.
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