ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Fibroblast growth factor 8 regulates neocortical guidance of area-specific thalamic innervation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 102 citations in OpenAlex.
- Sensory modality-specific wiring of thalamocortical circuits.Nature reviews. Neuroscience · 2025Review
- Development and Evolution of Thalamocortical Connectivity.Cold Spring Harbor perspectives in biology · 2024Review
- Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Roles of Fibroblast Growth Factors in the Axon Guidance.International journal of molecular sciences · 2023Review
- Step by step: cells with multiple functions in cortical circuit assembly.Nature reviews. Neuroscience · 2022Review
- Article
- Structural and Functional Aspects of the Neurodevelopmental GeneFrontiers in molecular neuroscience · 2021Review
- Modelling the emergence of whisker barrels.eLife · 2020Article
- Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates.Cell reports · 2020Article
- Editorial: The Earliest-Born Cortical Neurons as Multi-Tasking Pioneers: Expanding Roles for Subplate Neurons in Cerebral Cortex Organization and Function.Frontiers in neuroanatomy · 2020Article
- Limit cycle dynamics can guide the evolution of gene regulatory networks towards point attractors.Scientific reports · 2019Article
- Development and Arealization of the Cerebral Cortex.Neuron · 2019Review
- Precision in the development of neocortical architecture: From progenitors to cortical networks.Progress in neurobiology · 2019Review
- Developmental interactions between thalamus and cortex: a true love reciprocal story.Current opinion in neurobiology · 2018Review
- Development of the Thalamocortical Interactions: Past, Present and Future.Neuroscience · 2018Review
- Impact of thalamocortical input on barrel cortex development.Neuroscience · 2018Review
- Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex.Frontiers in neuroscience · 2015Review
- Parsing out the embryonic origin of subplate cell-type diversity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Evolution and development of the mammalian cerebral cortex.Brain, behavior and evolution · 2014Article
- Evolution and development of interhemispheric connections in the vertebrate forebrain.Frontiers in human neuroscience · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Thalamic innervation of each neocortical area is vital to cortical function, but the developmental strategies that guide axons to specific areas remain unclear. We took a new approach to determine the contribution of intracortical cues. The cortical patterning molecule fibroblast growth factor 8 (FGF8) was misexpressed in the cortical primordium to rearrange the area map. Thalamic axons faithfully tracked changes in area position and innervated duplicated somatosensory barrel fields induced by an ectopic source of FGF8, indicating that thalamic axons indeed use intracortical positional information. Because cortical layers are generated in temporal order, FGF8 misexpression at different ages could be used to shift regional identity in the subplate and cortical plate either in or out of register. Thalamic axons showed strikingly different responses in the two different conditions, disclosing sources of positional guidance in both subplate and cortical plate. Unexpectedly, axon trajectories indicated that an individual neocortical layer could provide not only laminar but also area-specific guidance. Our findings demonstrate that thalamocortical axons are directed by sequential, positional cues within the cortex and implicate FGF8 as an indirect regulator of thalamocortical innervation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.