ArticleAmerican journal of physiology. Cell physiology2005
TFF3 modulates NF-{kappa}B and a novel negative regulatory molecule of NF-{kappa}B in intestinal epithelial cells via a mechanism distinct from TNF-{alpha}.
Article in American journal of physiology. Cell physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Overexpression of TFF3 is Associated with Immune Infiltration, Molecular Subtypes, and Clinical Progression in Breast Cancer.Current medical science · 2026Article
- A Network-Based Association of IBD and Colorectal Cancer Using Proteomics Data.Proteomics. Clinical applications · 2026Article
- Comprehensive assessment of cellular senescence in intestinal immunity and biologic therapy response in ulcerative colitis.Scientific reports · 2024Article
- Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective.Cell death & disease · 2022Review
- TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths.Nature communications · 2019Article
- The expression and role of trefoil factors in human tumors.Translational cancer research · 2019Review
- Trefoil factors peptide-3 is associated with residual invasive breast carcinoma following neoadjuvant chemotherapy.BMC cancer · 2019Article
- The predictive powers of plasma trefoil factor 3 or its related micro RNAs for patients with hepatocellular carcinoma.BMC cancer · 2018Article
- Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice.Molecular medicine (Cambridge, Mass.) · 2017Article
- Release of HER2 repression of trefoil factor 3 (TFF3) expression mediates trastuzumab resistance in HER2+/ER+ mammary carcinoma.Oncotarget · 2017Article
- Expression of trefoil factors and TWIST1 in colorectal cancer and their correlation with metastatic potential and prognosis.World journal of gastroenterology · 2017Article
- Proteome analysis of the macroscopically affected colonic mucosa of Crohn's disease and intestinal tuberculosis.Scientific reports · 2016Article
- Recombinant human trefoil factor 3 ameliorates bowel injury: its anti-inflammatory effect on experimental necrotizing enterocolitis.International journal of peptides · 2014Article
- Activation of the NF-kB pathway downregulates TFF-1 in gastric carcinogenesis.Virchows Archiv : an international journal of pathology · 2013Article
- In Vitro Investigation of the Immunomodulatory Potential of Probiotic Lactobacillus casei.Probiotics and antimicrobial proteins · 2013Article
- PI3K/Akt signaling pathway in the basolateral amygdala mediates the rapid antidepressant-like effects of trefoil factor 3.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression.Neoplasia (New York, N.Y.) · 2010Article
- Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells.Cancer cell · 2010Article
- Toll-like receptor 2-mediated peptidoglycan uptake by immature intestinal epithelial cells from apical side and exosome-associated transcellular transcytosis.Journal of cellular physiology · 2010Article
- Effects of trefoil peptide 3 on expression of TNF-alpha, TLR4, and NF-kappaB in trinitrobenzene sulphonic acid induced colitis mice.Inflammation · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Trefoil factor 3 (intestinal trefoil factor) is a cytoprotective factor in the gut. Herein we compared the effect of trefoil factor 3 with tumor necrosis factor-alpha on 1) activation of NF-kappaB in intestinal epithelial cells; 2) expression of Twist protein (a molecule essential for downregulation of nuclear factor-kappaB activity in vivo); and 3) production of interleukin-8. We showed that Twist protein is constitutively expressed in intestinal epithelial cells. Tumor necrosis factor-alpha induced persistent degradation of Twist protein in intestinal epithelial cells via a signaling pathway linked to proteasome, which was associated with prolonged activation of NF-kappaB. In contrast to tumor necrosis factor, trefoil factor 3 triggered transient activation of NF-kappaB and prolonged upregulation of Twist protein in intestinal epithelial cells via an ERK kinase-mediated pathway. Unlike tumor necrosis factor-alpha, transient activation of NF-kappaB by trefoil factor 3 is not associated with induction of IL-8 in cells. To examine the role of Twist protein in intestinal epithelial cells, we silenced the Twist expression by siRNA. Our data showed that trefoil factor 3 induced interleukin-8 production after silencing Twist in intestinal epithelial cells. Together, these observations indicated that 1) trefoil factor 3 triggers a diverse signal from tumor necrosis factor-alpha on the activation of NF-kappaB and its associated molecules in intestinal epithelial cells; and 2) trefoil factor 3-induced Twist protein plays an important role in the modulation of inflammatory cytokine production in intestinal epithelial cells.
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