ArticleAmerican journal of physiology. Cell physiology2005
Somatic vs. dendritic responses to hypercapnia in chemosensitive locus coeruleus neurons from neonatal rats.
Article in American journal of physiology. Cell physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025Review
- Criteria for central respiratory chemoreceptors: experimental evidence supporting current candidate cell groups.Frontiers in physiology · 2023Review
- Adaptation of Respiratory-Related Brain Regions to Long-Term Hypercapnia: Focus on Neuropeptides in the RTN.Frontiers in neuroscience · 2019Article
- Theoretical perspectives on central chemosensitivity: CO2/H+-sensitive neurons in the locus coeruleus.PLoS computational biology · 2017Article
- Impaired central respiratory chemoreflex in an experimental genetic model of epilepsy.The Journal of physiology · 2017Article
- A HCO(3)(-)-dependent mechanism involving soluble adenylyl cyclase for the activation of Ca²⁺ currents in locus coeruleus neurons.Biochimica et biophysica acta · 2014Article
- Substance P differentially modulates firing rate of solitary complex (SC) neurons from control and chronic hypoxia-adapted adult rats.PloS one · 2014Article
- Transient outwardly rectifying A currents are involved in the firing rate response to altered CO2 in chemosensitive locus coeruleus neurons from neonatal rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Postnatal development and activation of L-type Ca2+ currents in locus ceruleus neurons: implications for a role for Ca2+ in central chemosensitivity.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Regulation of visceral sympathetic tone by A5 noradrenergic neurons in rodents.The Journal of physiology · 2011Article
- The locus coeruleus and central chemosensitivity.Respiratory physiology & neurobiology · 2010Review
- Central respiratory chemoreception.The Journal of comparative neurology · 2010Review
- CO2 chemoreception in cardiorespiratory control.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Neuronal expression of sodium/bicarbonate cotransporter NBCn1 (SLC4A7) and its response to chronic metabolic acidosis.American journal of physiology. Cell physiology · 2010Article
- Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Negative shift in the glycine reversal potential mediated by a Ca2+- and pH-dependent mechanism in interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Characterization of the chemosensitive response of individual solitary complex neurons from adult rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- GFP-expressing locus ceruleus neurons from Prp57 transgenic mice exhibit CO2/H+ responses in primary cell culture.Journal of applied physiology (Bethesda, Md. : 1985) · 2008Article
- Somatic vs. dendritic responses to hypercapnia in chemosensitive locus coeruleus neurons from neonatal rats.American journal of physiology. Cell physiology · 2005Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiorespiratory control is mediated in part by central chemosensitive neurons that respond to increased CO(2) (hypercapnia). Activation of these neurons is thought to involve hypercapnia-induced decreases in intracellular pH (pH(i)). All previous measurements of hypercapnia-induced pH(i) changes in chemosensitive neurons have been obtained from the soma, but chemosensitive signaling could be initiated in the dendrites of these neurons. In this study, membrane potential (V(m)) and pH(i) were measured simultaneously in chemosensitive locus coeruleus (LC) neurons from neonatal rat brain stem slices using whole cell pipettes and the pH-sensitive fluorescent dye pyranine. We measured pH(i) from the soma as well as from primary dendrites to a distance 160 mum from the edge of the soma. Hypercapnia [15% CO(2), external pH (pH(o)) 7.00; control, 5% CO(2), pH(o) 7.45] resulted in an acidification of similar magnitude in dendrites and soma ( approximately 0.26 pH unit), but acidification was faster in the more distal regions of the dendrites. Neither the dendrites nor the soma exhibited pH(i) recovery during hypercapnia-induced acidification; but both regions contained pH-regulating transporters, because they exhibited pH(i) recovery from an NH(4)Cl prepulse-induced acidification (at constant pH(o) 7.45). Exposure of a portion of the dendrites to hypercapnic solution did not increase the firing rate, but exposing the soma to hypercapnic solution resulted in a near-maximal increase in firing rate. These data show that while the pH(i) response to hypercapnia is similar in the dendrites and soma, somatic exposure to hypercapnia plays a major role in the activation of chemosensitive LC neurons from neonatal rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.