ArticleMolecular biology of the cell2005
Induction of cytokinesis is independent of precisely regulated microtubule dynamics.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Use of Echinoderm Gametes and Early Embryos for Studying Meiosis and Mitosis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Polar relaxation by dynein-mediated removal of cortical myosin II.The Journal of cell biology · 2020Article
- Review
- Shape-motion relationships of centering microtubule asters.The Journal of cell biology · 2016Article
- Influence of cell polarity on early development of the sea urchin embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Localization of cytokinesis factors to the future cell division site by microtubule-dependent transport.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Polar expansion during cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Temporal evaluation of cardiac myocyte hypertrophy and hyperplasia in male rats secondary to chronic volume overload.The American journal of pathology · 2010Article
- Making the cut: the chemical biology of cytokinesis.ACS chemical biology · 2010Review
- Action at a distance during cytokinesis.The Journal of cell biology · 2009Article
- Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells.The Journal of cell biology · 2009Article
- Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells.The Journal of cell biology · 2008Article
- Physical model of contractile ring initiation in dividing cells.Biophysical journal · 2008Article
- GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.Developmental cell · 2007Article
- A global, myosin light chain kinase-dependent increase in myosin II contractility accompanies the metaphase-anaphase transition in sea urchin eggs.Molecular biology of the cell · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Astral microtubules (MTs) emanating from the mitotic apparatus (MA) during anaphase are required for stimulation of cytokinesis in eggs. We have used green fluorescent protein-labeled EB1 to observe MT dynamics during mitosis and cytokinesis in normal sea urchin eggs. Analysis of astral MT growth rates during anaphase shows that MTs contact the polar cortex earlier than the equatorial cortex after anaphase onset but that a normal cleavage furrow is not induced until contact with MTs has been achieved throughout the cortex. To assess the role of MT dynamics in initiation of cytokinesis, we used a collection of small molecule drugs to affect dynamics. Hexylene glycol resulted in rapid astral elongation due to decreased MT catastrophe and precocious furrowing. Taxol suppressed MT dynamics but did not inhibit furrow induction when the MA was manipulated toward the cortex. Urethane resulted in short, highly dynamic astral MTs with increased catastrophe that also stimulated furrowing upon being brought into proximity to the cortex. Our findings indicate that astral MT contact with the cortex is necessary for furrow initiation but that the dynamic state of astral MTs does not affect their competency to stimulate furrowing.
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