ArticleMolecular biology of the cell2005
Fzf1p regulates an inducible response to nitrosative stress in Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Zinc-finger transcription factor Fzf1 binds to its target DNA in a non-canonical manner.Nucleic acids research · 2026Article
- Zinc-Finger 5 Is an Activation Domain in theJournal of fungi (Basel, Switzerland) · 2025Article
- Article
- The Metabolic Regulation of Amino Acid Synthesis Counteracts Reactive Nitrogen Stress viaJournal of fungi (Basel, Switzerland) · 2024Article
- Transcriptional activation of budding yeast DDI2/3 through chemical modifications of Fzf1.Cell biology and toxicology · 2023Article
- Nitrate and Phosphate Transporters Rescue Fluoride Toxicity in Yeast.Chemical research in toxicology · 2019Article
- S-nitrosylation of the zinc finger protein SRG1 regulates plant immunity.Nature communications · 2018Article
- Stress Adaptation.Microbiology spectrum · 2017Review
- Adaptation ofGenetics · 2017Article
- Globins Scavenge Sulfur Trioxide Anion Radical.The Journal of biological chemistry · 2015Article
- Ecological and Genetic Barriers Differentiate Natural Populations of Saccharomyces cerevisiae.Molecular biology and evolution · 2015Article
- Defining the transcriptomic landscape of Candida glabrata by RNA-Seq.Nucleic acids research · 2015Article
- Nitric oxide: an effective weapon of the plant or the pathogen?Molecular plant pathology · 2014Review
- Molecular components of nitrate and nitrite efflux in yeast.Eukaryotic cell · 2014Article
- Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.Science (New York, N.Y.) · 2013Article
- NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin.Nature chemical biology · 2013Article
- Factors supporting cysteine tolerance and sulfite production in Candida albicans.Eukaryotic cell · 2013Article
- Hemoglobin: a nitric-oxide dioxygenase.Scientifica · 2012Review
- Divergence of the yeast transcription factor FZF1 affects sulfite resistance.PLoS genetics · 2012Article
- A genetic analysis of nitric oxide-mediated signaling during chronological aging in the yeast.Biogerontology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms by which microorganisms sense and detoxify nitric oxide (*NO) are of particular interest due to the central role this molecule plays in innate immunity. We investigated the genetic basis of inducible nitric oxide (*NO) detoxification in Saccharomyces cerevisiae by characterizing the genome-wide transcriptional response to exogenously supplied *NO. Exposure to the *NO-generating compound dipropylenetriamine NONOate resulted in both a general stress response as well as a specific response characterized by the induction of a small set of genes, including the yeast flavohemoglobin YHB1, SSU1, and three additional uncharacterized open reading frames. Transcriptional induction of SSU1, which encodes a putative sulfite transporter, has previously been shown to require the zinc finger transcription factor Fzf1p. Deletion of Fzf1p eliminated the nitrosative stress-specific transcriptional response, whereas overexpression of Fzf1p recapitulated this response in the absence of exogenously supplied *NO. A cis-acting sequence unique to the promoter regions of Fzf1p-dependent genes was found to be sufficient to activate reporter gene activity in an *NO- and Fzf1p-dependent manner. Our results suggest that the presence of *NO or *NO derivatives activates Fzf1p leading to transcriptional induction of a discrete set of target genes that function to protect the cell from *NO-mediated stress.
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