ReviewChromosoma2005
Kiss and break up--a safe passage to anaphase in mitosis and meiosis.
Review in Chromosoma, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 18 citations in OpenAlex.
- Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies.Frontiers in genetics · 2012Article
- A zebrafish model of Roberts syndrome reveals that Esco2 depletion interferes with development by disrupting the cell cycle.PloS one · 2011Article
- Emerging roles for centromeres in meiosis I chromosome segregation.Nature reviews. Genetics · 2008Review
- The many facets of SC function during C. elegans meiosis.Chromosoma · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic chromosomes have many challenges to overcome between DNA replication and sister chromatid segregation. If these challenges are not met, cell death or unregulated cell division (cancer) may result. During prophase, chromosomes condense, the nuclear membrane breaks down and cohesins are removed from chromosome arms. In prometaphase, initial spindle attachments are made by sister kinetochores followed by correction of erroneous attachments, centromere oscillation between spindle poles and congression towards the cell's equator. In metaphase, all chromosomes attain stable bipolar spindle attachments and align at the metaphase plate, ready for the metaphase-anaphase transition when all ties between sister chromatids are broken. This review concentrates on recent developments that have revealed the intricacies of these processes. We now know more about how the mechanisms of cohesin removal differ between prophase and the metaphase-anaphase transition, the processes for detection and correction of improper spindle-kinetochore attachments and the concept that tension between sister kinetochores is the driving factor for satisfying the spindle checkpoint. We are also beginning to gain some understanding of the mechanisms behind the co-segregation of sister chromatids at the first meiotic division.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.