ReviewChromosoma2005
The mechanism of telomere protection: a comparison between Drosophila and humans.
Review in Chromosoma, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 96 citations in OpenAlex.
- Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution.Genome research · 2026Article
- Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila.BMC biology · 2025Article
- Low dose rate γ-irradiation protects fruit fly chromosomes from double strand breaks and telomere fusions by reducing the esi-RNA biogenesis factor Loquacious.Communications biology · 2022Article
- Condensin II subunit NCAPH2 associates with shelterin protein TRF1 and is required for telomere stability.Journal of cellular physiology · 2019Article
- Germline-Specific Repetitive Elements in Programmatically Eliminated Chromosomes of the Sea Lamprey (Genes · 2019Article
- The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities.International journal of molecular sciences · 2018Review
- Article
- Drosophila: Retrotransposons Making up Telomeres.Viruses · 2017Review
- Life and cancer without telomerase: ALT and other strategies for making sure ends (don't) meet.Critical reviews in biochemistry and molecular biology · 2017Review
- The Deadbeat Paternal Effect of Uncapped Sperm Telomeres on Cell Cycle Progression and Chromosome Behavior in Drosophila melanogaster.Genetics · 2016Article
- The hnRNP A1 homolog Hrb87F/Hrp36 is important for telomere maintenance in Drosophila melanogaster.Chromosoma · 2016Article
- A role for Separase in telomere protection.Nature communications · 2016Article
- Telomeric repeat silencing in germ cells is essential for early development in Drosophila.Nucleic acids research · 2015Article
- Protection of Drosophila chromosome ends through minimal telomere capping.Journal of cell science · 2015Article
- Article
- Cross-Species Interaction between Rapidly Evolving Telomere-Specific Drosophila Proteins.PloS one · 2015Article
- Article
- Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish.Current molecular pharmacology · 2014Article
- Article
- Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres.Frontiers in oncology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila telomeres are maintained by transposition of specialized retrotransposons rather than by telomerase activity, and their stability is independent of the sequence of DNA termini. Recent studies have identified several proteins that protect Drosophila telomeres from fusion events. These proteins include the telomere capping factors HP1/ORC-associated protein (HOAP) and heterochromatin protein 1 (HP1), the Rad50 and Mre11 DNA repair proteins that are required for HOAP and HP1 localization at telomeres, and the ATM kinase. Another telomere-protecting factor identified in Drosophila is UbcD1, a polypeptide highly homologous to class I ubiquitin-conjugating E2 enzymes. In addition, it has been shown that HP1 and both components of the Drosophila Ku70/80 heterodimer act as negative regulators of telomere length. Except for HOAP, all these proteins are conserved in humans and are associated with human telomeres. Collectively, these results indicate that Drosophila is an excellent model system for the analysis of the mechanisms of telomere maintenance. In past and current studies, 15 Drosophila genes have been identified that prevent telomeric fusion, and it has been estimated that the Drosophila genome contains at least 40 genes required for telomere protection. We believe that the molecular characterization of these genes will lead to identification of many novel human genes with roles in telomere maintenance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.