ArticleEuropean journal of pediatrics2005
Severe persistent pulmonary hypertension of the newborn in a setting where limited resources exclude the use of inhaled nitric oxide: successful treatment with sildenafil.
Article in European journal of pediatrics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Sildenafil for pulmonary hypertension in neonates.The Cochrane database of systematic reviews · 2017Pooled it
- Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial.Paediatric drugs · 2020Trial
- Clinical Efficacy and Safety of Different Doses of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of the Newborn: A Network Meta-analysis.Frontiers in pharmacology · 2021Article
- Pharmacokinetics of sildenafil in children with pulmonary arterial hypertension.World journal of pediatrics : WJP · 2017Article
- Persistent pulmonary hypertension of the newborn.Maternal health, neonatology and perinatology · 2015Article
- Is sildenafil an effective therapy in the management of persistent pulmonary hypertension?Journal of clinical neonatology · 2012Review
- Cardiotoxicity in childhood cancer survivors: strategies for prevention and management.Future cardiology · 2012Review
- Effect of a phosphodiesterase 5 inhibitor on pulmonary and cerebral arteries of newborn piglets with chronic hypoxia-induced pulmonary hypertension.Neonatology · 2012Article
- Initial Experience with Sildenafil, Bosentan, and Nitric Oxide for Pediatric Cardiomyopathy Patients with Elevated Pulmonary Vascular Resistance before and after Orthotopic Heart Transplantation.Journal of transplantation · 2010Article
- Sildenafil for the treatment of pulmonary hypertension in pediatric patients.Pediatric cardiology · 2009Review
- Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury.Respiratory research · 2009Article
- Molecular pathogenesis of pulmonary arterial hypertension.The Journal of clinical investigation · 2008Review
- Therapeutic applications of sildenafil citrate in the management of paediatric pulmonary hypertension.Drugs · 2007Review
- Sildenafil in the treatment of pulmonary hypertension.Vascular health and risk management · 2006Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledWe present the case of a full term neonate with severe persistent pulmonary hypertension of the newborn (PPHN) after birth asphyxia cared for at the St. Elizabeth Hospital in Curacao, Netherlands Antilles. Although the child was ventilated with high pressures and was given high doses of cardiovascular pressors, the arterial oxygen levels remained low with an alveolar-arterial O2 gradient of 651 mmHg. As a last resort, sildenafil (1.5 mg/kg) was given via a nasogastric tube. This resulted in an immediate and sustained elevation of arterial oxygenation and subsequent complete recovery. After administration of sildenafil there was a transient hypotension which was corrected by a single bolus of saline.
conclusionWe discuss the current treatment modalities of persistent pulmonary hypertension of the newborn and the potential use of phosphodiesterase 5 inhibitors such as sildenafil in a situation where the standard of practice with inhaled nitric oxide and extracorporeal membrane oxygenation is not available.
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