ArticleVirchows Archiv : an international journal of pathology2005
The endothelin/nitric oxide balance determines small-for-size liver injury after reduced-size rat liver transplantation.
Article in Virchows Archiv : an international journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Two grafts, one implant:Hepatobiliary surgery and nutrition · 2026Article
- Hepatic Arterial Buffer Response in Liver Transplant Recipients: Implications and Treatment Options.Seminars in interventional radiology · 2023Review
- Effects of heme oxygenase-1-modified bone marrow mesenchymal stem cells on microcirculation and energy metabolism following liver transplantation.World journal of gastroenterology · 2017Article
- Small-for-size syndrome in living-donor liver transplantation using a left lobe graft.Surgery today · 2015Review
- G-CSF pretreatment aggravates LPS-associated microcirculatory dysfunction and acute liver injury after partial hepatectomy in rats.Histochemistry and cell biology · 2014Article
- Endothelin-1 receptor A blocker darusentan decreases hepatic changes and improves liver repopulation after cell transplantation in rats.Hepatology (Baltimore, Md.) · 2014Article
- Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli.Experimental and molecular pathology · 2013Article
- HTK-N, a modified HTK solution, decreases preservation injury in a model of microsteatotic rat liver transplantation.Langenbeck's archives of surgery · 2012Article
- A critical appraisal of the hemodynamic signal driving liver regeneration.Langenbeck's archives of surgery · 2012Review
- [Small-for-size: experimental findings for liver surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2012Review
- Hyperbaric oxygen therapy reduces the severity of ischaemia, preservation and reperfusion injury in a rat model of liver transplantation.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2012Article
- Regulation of hepatic blood flow: the hepatic arterial buffer response revisited.World journal of gastroenterology · 2010Review
- Morphologic features in the regenerating liver--a comparative intravital, lightmicroscopical and ultrastructural analysis with focus on hepatic stellate cells.Virchows Archiv : an international journal of pathology · 2007Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small-for-size (SFS) liver graft injury is probably related to microcirculatory disorders due to an imbalance of vasoconstricting, e.g. endothelin (ET)-1, and vasorelaxing mediators, e.g. nitric oxide (NO). We studied the role of ET-1/NO balance and the effect of an endothelin A receptor (ETAR) antagonist on SFS injury after liver resection and reduced-size liver transplantation (RSLT). One hundred twenty-six Lewis rats were divided into five groups: (I) 70% liver resection, (II) 70% liver resection treated with the ETAR antagonist LU 135252 (1 mg/kg b.w. i.v.), (III) RSLT (30% residual liver volume), (IV) RSLT treated with the ETAR antagonist, (V) sham operation. Liver microcirculation was measured by intravital microscopy. ET-1, ETAR, endothelial NO-synthase (eNOS), activation of Kupffer cells (KCs) and parenchymal injury were studied by immunohistology. Survival and liver function were followed up to 14 days. RSLT led to increased ET-1, ETAR and decreased eNOS protein expression, accompanied by activation of KC, reduced perfusion rate, vasoconstriction and elevated sinusoidal blood flow, as well as hepatocellular damage, impaired liver function and impaired survival. ETAR blockade (groups II + IV) improved the ET-1/NO balance, attenuated microcirculatory disorders and improved hepatocellular apoptosis and liver function. Microcirculatory disorders related to an ET-1/NO imbalance may contribute to SFS liver injury. Maintenance of ET-1/NO balance by blocking ETAR reduces SFS injury by protecting liver microcirculation, thus reducing hepatocellular damage.
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