ReviewJournal of molecular neuroscience : MN2005
Receptor-receptor interactions, receptor mosaics, and basic principles of molecular network organization: possible implications for drug development.
Review in Journal of molecular neuroscience : MN, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes.International journal of molecular sciences · 2023Article
- Drug-resistant epilepsy: Drug target hypothesis and beyond the receptors.Epilepsia open · 2022Review
- Heterodimer of A2A and Oxytocin Receptors Regulating Glutamate Release in Adult Striatal Astrocytes.International journal of molecular sciences · 2022Article
- Modulating brain integrative actions as a new perspective on pharmacological approaches to neuropsychiatric diseases.Frontiers in endocrinology · 2022Review
- The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?Frontiers in pharmacology · 2019Review
- The brain as a "hyper-network": the key role of neural networks as main producers of the integrated brain actions especially via the "broadcasted" neuroconnectomics.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.Nature communications · 2018Article
- Information handling by the brain: proposal of a new "paradigm" involving the roamer type of volume transmission and the tunneling nanotube type of wiring transmission.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Probing the Arabidopsis flagellin receptor: FLS2-FLS2 association and the contributions of specific domains to signaling function.The Plant cell · 2012Article
- Molecular pathways in dystonia.Neurobiology of disease · 2011Review
- On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.Journal of receptor and signal transduction research · 2010Review
- Triplet puzzle: homologies of receptor heteromers.Journal of molecular neuroscience : MN · 2010Article
- Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders.CNS neuroscience & therapeutics · 2010Review
- Theoretical considerations on the topological organization of receptor mosaics.Current protein & peptide science · 2009Review
- A boolean network modelling of receptor mosaics relevance of topology and cooperativity.Journal of neural transmission (Vienna, Austria : 1996) · 2007Review
- The brain as a system of nested but partially overlapping networks. Heuristic relevance of the model for brain physiology and pathology.Journal of neural transmission (Vienna, Austria : 1996) · 2007Review
- Intramembrane receptor-receptor interactions: a novel principle in molecular medicine.Journal of neural transmission (Vienna, Austria : 1996) · 2007Review
- Receptor-receptor interactions in central cardiovascular regulation. Focus on neuropeptide/alpha(2)-adrenoreceptor interactions in the nucleus tractus solitarius.Journal of neural transmission (Vienna, Austria : 1996) · 2007Review
- Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseases.Neuromolecular medicine · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The phenomenon of receptor-receptor interactions was hypothesized by Agnati and Fuxe in the 1980s, and several indirect proofs were provided in the following years by means of in vitro binding experiments and in vivo experiments in physiological and pathological animal models. This paper aims to outline some of the most important features and consequences of this phenomenon in the frame of the structural and functional aspects of molecular networks. In particular, the concepts of receptor mosaic (RM), and of horizontal and vertical molecular networks (HMNs, VMNs, respectively) are illustrated. To discuss some aspects of the functional organization of molecular networks, not only new data on protein-protein interactions but also the biochemical mechanism of cooperativity will be used. On this basis, some theoretical deductions can be drawn that allow a tentative classification of the RMs and the proposal of the extension of the concept of branching point introduced for enzymes to the possible switching role of some RMs in directing signals to various VMNs. Finally, the cooperativity phenomenon and the so-called symmetry rule will be used to introduce a proper mathematical approach that characterizes RMs as to their receptor composition, receptor topography, and order of receptor activation inside the RM. These new data on G protein-coupled receptors and molecular network organization indicate possible new approaches for drug development.
Indexed as
Identifiers
16012193What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.