ReviewJournal of molecular neuroscience : MN2005
How proteins come together in the plasma membrane and function in macromolecular assemblies: focus on receptor mosaics.
Review in Journal of molecular neuroscience : MN, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Information handling by the brain: proposal of a new "paradigm" involving the roamer type of volume transmission and the tunneling nanotube type of wiring transmission.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.Journal of receptor and signal transduction research · 2010Review
- Differential sensitivity of A2A and especially D2 receptor trafficking to cocaine compared with lipid rafts in cotransfected CHO cell lines. Novel actions of cocaine independent of the DA transporter.Journal of molecular neuroscience : MN · 2010Article
- Theoretical considerations on the topological organization of receptor mosaics.Current protein & peptide science · 2009Review
- Mosaic, self-similarity logic, and biological attraction principles: three explanatory instruments in biology.Communicative & integrative biology · 2009Article
- Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synuclein.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Implications of the 'Energide' concept for communication and information handling in the central nervous system.Journal of neural transmission (Vienna, Austria : 1996) · 2009Review
- On the key role played by altered protein conformation in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2008Review
- Intramembrane receptor-receptor interactions: a novel principle in molecular medicine.Journal of neural transmission (Vienna, Austria : 1996) · 2007Review
- Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state.The Biochemical journal · 2006Article
- Receptor-receptor interactions, receptor mosaics, and basic principles of molecular network organization: possible implications for drug development.Journal of molecular neuroscience : MN · 2005Review
- Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in Alzheimer's disease patients and in Parkinson's disease patients.Neurotoxicity research · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Some theoretical aspects on structure and function of proteins have been discussed previously. Proteins form multimeric complexes, as they have the capability of binding other proteins (Lego property) resulting in multimeric complexes capable of emergent functions. Multimeric proteins might have either a genomic or a postgenomic origin. Proteins spanning the plasma membrane have been analyzed by considering the effects of the microenvironment in which the protein is embedded. In particular, the different effects of the hydrophilic (extracellular and intracellular) versus the lipophilic (intramembrane) environment have been considered. These aspects have been discussed in the framework of membrane microdomains, in particular, the so-called rafts. In alpha-helix proteins the individual peptide dipoles align to produce a macrodipole crossing the entire membrane. This macrodipole has its positive (extracellular) pole at the N-terminal end of the helix and its negative (intracellular) pole at the C-terminal end. This arrangement has been analyzed in the framework of the counter-ion atmosphere, that is, the formation of a cloud of small ions bearing an opposite charge. Excitable cells reverse their resting potential during the all-or-none action potentials. Hence, the extracellular side of the plasma membrane becomes negative with respect to the intracellular side. This change of polarization affects also the direction and magnitude of the alpha-helix dipole in view of the fact that there is a displacement of the counter ions. The oscillation in the intensity of the dipole caused by the action potentials opens the possibility of an interaction among dipoles by electromagnetic waves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.