ReviewJournal of anatomy2005
From nociception to pain perception: imaging the spinal and supraspinal pathways.
Review in Journal of anatomy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04125121 (Neuroplasticity Induced by General Anaesthesia), which is not on this map. Cited by 127 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroplasticity Induced by General Anaesthesia
Who cites it
127 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Meta-analytic evidence for distinct neural correlates of conditioned versus verbally induced placebo analgesia.Nature communications · 2026Pooled it
- Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data.Nature communications · 2021Pooled it
- Invasive Motor Cortex Stimulation Influences Intracerebral Structures in Patients With Neuropathic Pain: An Activation Likelihood Estimation Meta-Analysis of Imaging Data.Neuromodulation : journal of the International Neuromodulation Society · 2020Pooled it
- Alterations in grey matter density and functional connectivity in trigeminal neuropathic pain and trigeminal neuralgia: A systematic review and meta-analysis.NeuroImage. Clinical · 2019Pooled it
- Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge.PloS one · 2019Trial
- Venlafaxine and oxycodone have different effects on spinal and supraspinal activity in man: a somatosensory evoked potential study.British journal of clinical pharmacology · 2017Trial
- Effect of acupuncture 'dose' on modulation of the default mode network of the brain.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2016Trial
- Cortical pain responses in human infants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Trial
- Temporal Interference Stimulation of the Motor Cortex Produces Frequency-Dependent Analgesia.bioRxiv : the preprint server for biology · 2026Article
- Electrotherapy in the management of neuropathic corneal pain: narrative review.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- Pain and the Brain: A Systematic Review of Methods, EEG Biomarkers, Limitations, and Future Directions.Neurology international · 2025Review
- Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populations.Translational psychiatry · 2025Review
- ANXIETY, FEARS AND FEAR-AVOIDANCE BELIEFS AND THERAPEUTIC OUTCOME AFTER LUMBAR MICRODISCECTOMY.Acta clinica Croatica · 2024Article
- Thermal stimulus task fMRI in the cervical spinal cord at 7 Tesla.Human brain mapping · 2024Article
- Pain mechanisms in the transgender individual: a review.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation.Neural regeneration research · 2023Article
- Review
- The waiting game: investigating the neurobiological transition from acute to persistent pain in adolescent rats.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Chronic Pain-Associated Cardiovascular Disease: The Role of Sympathetic Nerve Activity.International journal of molecular sciences · 2023Review
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional imaging techniques have allowed researchers to look within the brain, and revealed the cortical representation of pain. Initial experiments, performed in the early 1990s, revolutionized pain research, as they demonstrated that pain was not processed in a single cortical area, but in several distributed brain regions. Over the last decade, the roles of these pain centres have been investigated and a clearer picture has emerged of the medial and lateral pain system. In this brief article, we review the imaging literature to date that has allowed these advances to be made, and examine the new frontiers for pain imaging research: imaging the brainstem and other structures involved in the descending control of pain; functional and anatomical connectivity studies of pain processing brain regions; imaging models of neuropathic pain-like states; and going beyond the brain to image spinal function. The ultimate goal of such research is to take these new techniques into the clinic, to investigate and provide new remedies for chronic pain sufferers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.