ArticleJournal of the American Chemical Society2005
Toward cocaine esterase therapeutics.
Article in Journal of the American Chemical Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (-)-Cocaine.Journal of chemical theory and computation · 2012Article
- Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity.Future medicinal chemistry · 2012Review
- Structural analysis of thermostabilizing mutations of cocaine esterase.Protein engineering, design & selection : PEDS · 2010Article
- PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
- Fundamental reaction mechanism and free energy profile for (-)-cocaine hydrolysis catalyzed by cocaine esterase.Journal of the American Chemical Society · 2009Article
- Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.Molecular pharmacology · 2009Article
- Rational design of an enzyme mutant for anti-cocaine therapeutics.Journal of computer-aided molecular design · 2008Review
- Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction.Organic & biomolecular chemistry · 2008Review
- Unexpected acetylcholinesterase activity of cocaine esterases.Journal of the American Chemical Society · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Cocaine is among the most reinforcing of all drugs of abuse, yet no effective pharmacotherapy is available. Herein, we report the development and characterization of phage-displayed cocaine esterases with pharmacologically relevant kinetic parameters (kcat/Km approximately 104 M-1 s-1).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.