ReviewExperientia1992
Peptidergic co-transmission in Aplysia: functional implications for rhythmic behaviors.
Review in Experientia, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Tradeoffs in the energetic value of neuromodulation in a closed-loop neuromechanical system.Journal of theoretical biology · 2025Article
- Peptidergic Modulation of the Lobster Cardiac System Has Opposing Action on Neurons and Muscles.Integrative organismal biology (Oxford, England) · 2025Article
- Full Hill-type muscle model of the I1/I3 retractor muscle complex in Aplysia californica.Biological cybernetics · 2024Article
- Neuromodulation Can Be Simple: Myoinhibitory Peptide, Contained in Dedicated Regulatory Pathways, Is the Only Neurally-Mediated Peptide Modulator of Stick Insect Leg Muscle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior inInternational journal of molecular sciences · 2021Review
- Comparative Analysis of Neuropeptides in Homologous Interneurons and Prohormone Annotation in Nudipleuran Sea Slugs.Frontiers in physiology · 2021Article
- Multiple Origins of Neurons From Secretory Cells.Frontiers in cell and developmental biology · 2021Article
- Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.ACS chemical neuroscience · 2018Review
- Substrates for Neuronal Cotransmission With Neuropeptides and Small Molecule Neurotransmitters inFrontiers in cellular neuroscience · 2018Review
- Preparing the periphery for a subsequent behavior: motor neuronal activity during biting generates little force but prepares a retractor muscle to generate larger forces during swallowing in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Motor neuronal activity varies least among individuals when it matters most for behavior.Journal of neurophysiology · 2015Article
- Release of a single neurotransmitter from an identified interneuron coherently affects motor output on multiple time scales.Journal of neurophysiology · 2013Article
- Review
- Composite modulatory feedforward loop contributes to the establishment of a network state.Journal of neurophysiology · 2010Article
- PRODUCTION OF NITRIC OXIDE WITHIN THE APLYSIA CALIFORNICA NERVOUS SYSTEM.ACS chemical neuroscience · 2010Article
- Feedback from peripheral musculature to central pattern generator in the neurogenic heart of the crab Callinectes sapidus: role of mechanosensitive dendrites.Journal of neurophysiology · 2010Article
- The peptide hormone pQDLDHVFLRFamide (crustacean myosuppressin) modulates the Homarus americanus cardiac neuromuscular system at multiple sites.The Journal of experimental biology · 2009Article
- Neural control of unloaded leg posture and of leg swing in stick insect, cockroach, and mouse differs from that in larger animals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- State dependence of network output: modeling and experiments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Review
- Changes of internal state are expressed in coherent shifts of neuromuscular activity in Aplysia feeding behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite their ubiquitous presence in the central and peripheral nervous systems, the behavioral functions of peptide co-transmitters remain to be elucidated. The marine mollusc Aplysia, whose simple nervous system facilitates the study of the neural basis of behavior, was used to investigate the role of peptidergic co-transmission in feeding behavior. Several novel modulatory neuropeptides were purified, and localized to identified cholinergic motorneurons. Physiological and biochemical studies demonstrated that these peptides are released when the motorneurons fire at frequencies that occur during normal behavior, and that the peptides modify the relationship between muscle contraction amplitude and relaxation rate so as to maintain optimal motor output when the intensity and frequency of feeding behavior change.
Indexed as
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1601110What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.