ArticleJournal of molecular medicine (Berlin, Germany)2005
Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients.
Article in Journal of molecular medicine (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Association between TLR2 and TLR4 Gene Polymorphisms and the Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis.PloS one · 2015Pooled it
- Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis.BMC gastroenterology · 2014Pooled it
- Linkage between genotype and immunological phenotype in Crohn's disease.Annals of translational medicine · 2015Article
- Dichotomal effect of space flight-associated microgravity on stress-activated protein kinases in innate immunity.Scientific reports · 2014Article
- Readressing the role of Toll-like receptor-4 alleles in inflammatory bowel disease: colitis, smoking, and seroreactivity.Digestive diseases and sciences · 2013Article
- Toll-like receptors and human disease: lessons from single nucleotide polymorphisms.Current genomics · 2012Article
- Role of tumor necrosis factor-alpha (C-863A) polymorphism in pathogenesis of inflammatory bowel disease in Northern India.Journal of gastrointestinal cancer · 2012Article
- Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo.PloS one · 2010Article
- Unleashing the therapeutic potential of NOD-like receptors.Nature reviews. Drug discovery · 2009Review
- Clustering of (auto)immune diseases with early-onset and complicated inflammatory bowel disease.European journal of pediatrics · 2009Article
- Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease.World journal of gastroenterology · 2008Article
- Dendritic cells and toll-like receptors 2 and 4 in the ileum of Crohn's disease patients.Digestive diseases and sciences · 2008Article
- The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- NOD takes its toll but stays in the CARDs in Crohn's disease.Journal of molecular medicine (Berlin, Germany) · 2005Article
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11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept that mutations in germ-line encoded pattern recognition receptors with immune activating functions are associated with an increased incidence in Crohn's disease (CD) is gaining acceptance. Whether these mutations have similar or distinct effects on cellular physiology remains obscure. The incidence of three single nucleotide polymorphisms (SNPs) within the Nod2 gene and one functional SNP within both the Tlr4 and Tlr5 gene in a Dutch cohort of 637 patients with inflammatory bowel disease and 127 controls was investigated. The functional consequence of mutant NOD2 and TLR4 was investigated by comparing gene expression profiles after stimulation of monocyte-derived dendritic cells (DCs) from homozygous TLR4- and NOD2-mutant patients with lipopolysaccharides and peptidoglycan, respectively. We observed that the R702W and 1007fs Nod2 alleles and the A299G Tlr4 alleles were significantly more prevalent in patients with CD as compared to healthy controls or patients with ulcerative colitis. The phenotype of TLR4- and NOD2-mutant DCs is distinct, but a large number of genes are up- or down-regulated concordantly. These data provide a concept for the genetic basis of CD; mutations in innate immunity cause similar effects on gene transcription and finally result in comparable clinical disease presentation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.