ArticleEuropean biophysics journal : EBJ2005
Fibronectin fibril pattern displays the force balance of cell-matrix adhesion.
Article in European biophysics journal : EBJ, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 31 citations in OpenAlex.
- Poly-L-Lysine and Human Plasmatic Fibronectin Films as Proactive Coatings to Improve Implant Biointegration.Frontiers in bioengineering and biotechnology · 2021Article
- Vitronectin as a Micromanager of Cell Response in Material-Driven Fibronectin Nanonetworks.Advanced biosystems · 2017Article
- Friction-controlled traction force in cell adhesion.Biophysical journal · 2011Article
- Article
- Immobilization of growth factors on solid supports for the modulation of stem cell fate.Nature protocols · 2010Article
- Dissecting the impact of matrix anchorage and elasticity in cell adhesion.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Formation of fibrillar patterns of fibronectin on polymer substrates with gradated physicochemical surface properties was analysed during early stages of endothelial cell adhesion. Fibronectin was pre-adsorbed onto three maleic anhydride copolymer thin films with distinct differences in the protein adsorption strength as verified by heteroexchange experiments. The evolved micrometer scale fibrillar patterns of fibronectin on the compared polymer surfaces were characterized after 50 min of cellular reorganization by an auto-correlation analysis using fluorescence microscopy data. Statistical analysis revealed a decrease of the typical spacings of the fibronectin fibrils from 2.6 to 1.8 mum with decreasing fibronectin adsorption strength to the substrate. Size and density of focal adhesions correlated with this dependence of the fibronectin fibril pattern. From these data a model was developed relating the fibronectin fibril pattern to the fibronectin-substrate adsorption strength through the cytoskeletal force regulation mechanism of the cell.
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