ArticleThe EMBO journal1992
Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 79 citations in OpenAlex.
- Aberrant synaptophysin expression in classic Hodgkin lymphoma.Diagnostic pathology · 2022Article
- Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Bayesian inference of negative and positive selection in human cancers.Nature genetics · 2017Article
- Regulation of tumor angiogenesis by the microtubule-binding protein CLIP-170.Protein & cell · 2013Article
- Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.Molecular biology of the cell · 2006Article
- The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis.Genes & development · 2005Article
- Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells.Oncogene · 2003Article
- The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase.EMBO reports · 2002Article
- Functional dissection and hierarchy of tubulin-folding cofactor homologues in fission yeast.Molecular biology of the cell · 1999Article
- A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of Drosophila embryos.The Journal of cell biology · 1998Article
- Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.The Journal of clinical investigation · 1997Article
- Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites.Molecular biology of the cell · 1997Article
- Kinesin-73 in the nervous system of Drosophila embryos.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cytolytic T lymphocyte responses of cancer patients to tumor-associated antigens.Springer seminars in immunopathology · 1996Review
- Human neoplasms elicit multiple specific immune responses in the autologous host.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Two microtubule-associated proteins required for anaphase spindle movement in Saccharomyces cerevisiae.The Journal of cell biology · 1995Article
- The Reed-Sternberg cells of Hodgkin disease are clonal.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.Nucleic acids research · 1993Article
- Characterization of a novel Hodgkin cell line, HD-MyZ, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice.The Journal of experimental medicine · 1993Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified a cDNA coding for a protein of 160 kDa which is expressed in in vitro cultured human peripheral blood monocytes. The predicted amino acid sequence contains an alpha-helical rod domain possessing features characteristic of intermediate filament proteins. However, the immunocytochemical staining pattern, abundance and solubility in Triton X-100/high salt buffers suggest that this protein is probably only associated with the intermediate filament network and represents a new type of intermediate filament associated protein. In a survey of normal, inflammatory and human tumour tissue samples, this protein, which we have named restin, was found to be highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. We suggest that restin overexpression may be a contributing factor in the progression of Hodgkin's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.