ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2005
Airway generation-specific differences in the spatial distribution of immune cells and cytokines in allergen-challenged rhesus monkeys.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung.American journal of respiratory cell and molecular biology · 2023Article
- Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells.Frontiers in immunology · 2021Article
- Organized lymphatic tissue (BALT) in lungs of rhesus monkeys after air pollutant exposure.Anatomical record (Hoboken, N.J. : 2007) · 2020Review
- Use of nonhuman primates in obstructive lung disease research - is it required?Primate biology · 2017Review
- Dynamics of IL-4 and IL-13 expression in the airways of sheep following allergen challenge.BMC pulmonary medicine · 2015Article
- Ozone-induced airway epithelial cell death, the neurokinin-1 receptor pathway, and the postnatal developing lung.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Ozone exposure alters serotonin and serotonin receptor expression in the developing lung.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Environmental tobacco smoke and progesterone alter lung inflammation and mucous metaplasia in a mouse model of allergic airway disease.Clinical reviews in allergy & immunology · 2012Article
- Lung epithelial healing: a modified seed and soil concept.Proceedings of the American Thoracic Society · 2012Article
- A cell-based computational modeling approach for developing site-directed molecular probes.PLoS computational biology · 2012Article
- Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model.The American journal of pathology · 2011Article
- Behavioral inhibition is associated with airway hyperresponsiveness but not atopy in a monkey model of asthma.Psychosomatic medicine · 2011Article
- Airway mast cells in a rhesus model of childhood allergic airways disease.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Cell-based multiscale computational modeling of small molecule absorption and retention in the lungs.Pharmaceutical research · 2010Article
- Ozone and allergen exposure during postnatal development alters the frequency and airway distribution of CD25+ cells in infant rhesus monkeys.Toxicology and applied pharmacology · 2009Article
- Differential distribution of inflammatory cells in large and small airways in smokers.Journal of clinical pathology · 2007Article
- Nonhuman primate models of asthma.The Journal of experimental medicine · 2005Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAccumulation of immune cell populations and their cytokine products within tracheobronchial airways contributes to the pathogenesis of allergic asthma. It has been postulated that peripheral regions of the lung play a more significant role than proximal airways with regard to inflammatory events and airflow obstruction.
objectiveTo determine whether immune cell populations and associated cytokines are uniformly distributed throughout the conducting airway tree in a non-human primate model of allergic asthma.
methodsWe used a stereologic approach with a stratified sampling scheme to measure the volume density of immune cells within the epithelium and interstitium of trachea and 4-5 intrapulmonary airway generations from house dust mite (HDM) (Dermatophagoides farinae)-challenged adult monkeys. In conjunction with immune cell distribution profiles, mRNA levels for 21 cytokines/chemokines and three chemokine receptors were evaluated at four different airway generations from microdissected lungs.
resultsIn HDM-challenged monkeys, the volume of CD1a+ dendritic cells, CD4+ T helper lymphocytes, CD25+ cells, IgE+ cells, eosinophils, and proliferating cells were significantly increased within airways. All five immune cell types accumulated within airways in unique patterns of distribution, suggesting compartmentalized responses with regard to trafficking. Although cytokine mRNA levels were elevated throughout the conducting airway tree of HDM-challenged animals, the distal airways (terminal and respiratory bronchioles) exhibited the most pronounced up-regulation.
conclusionThese findings demonstrate that key effector immune cell populations and cytokines associated with asthma differentially accumulate within distinct regions and compartments of tracheobronchial airways from allergen-challenged primates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.