ArticleOncogene2005
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 60 citations in OpenAlex.
- Role of c-Src in Carcinogenesis and Drug Resistance.Cancers · 2023Review
- Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development.Journal of mammary gland biology and neoplasia · 2023Article
- Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression.The Journal of clinical investigation · 2023Article
- Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo.Oncogene · 2021Review
- SRC IncreasesMolecular and cellular biology · 2018Article
- Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland.Oncogene · 2015Article
- Meaningful prevention of breast cancer metastasis: candidate therapeutics, preclinical validation, and clinical trial concerns.Journal of molecular medicine (Berlin, Germany) · 2015Review
- Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland.Developmental biology · 2014Article
- Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1.Development (Cambridge, England) · 2013Article
- Mouse mammary tumor virus suppresses apoptosis of mammary epithelial cells through ITAM-mediated signaling.Journal of virology · 2012Article
- Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Shorter disease-specific survival of ER-positive breast cancer patients with high cytoplasmic Src kinase expression after tamoxifen treatment.Journal of cancer research and clinical oncology · 2012Article
- C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.Advances in experimental medicine and biology · 2012Article
- Article
- Regulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification.The Journal of biological chemistry · 2011Article
- c-Jun N-terminal Kinase 2 Regulates Multiple Receptor Tyrosine Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis.Genes & cancer · 2011Article
- The contribution of adhesion signaling to lactogenesis.Journal of cell communication and signaling · 2010Article
- The role of Src in solid tumors.The oncologist · 2009Review
- Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer.Biochemical and biophysical research communications · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The c-Src tyrosine kinase has been implicated to play an integral role in modulating growth factor receptor, integrin and steroid receptor function. One class of steroid receptors that c-Src modulates is the estrogen receptor alpha (ERalpha). Although there is strong biochemical evidence supporting a role for c-Src in ERalpha signaling, the consequence of this association is unclear at the biological level. To explore the significance of c-Src in ERalpha signaling, we studied the development of various reproductive organs that are dependent on ERalpha in c-Src-deficient mice. We show that the loss of the c-Src tyrosine kinase correlates with defects in ductal development as well as in uterine and ovarian development. Genetic and biochemical analyses of c-Src-deficient mammary epithelial cells also revealed defects in the ability of mammary epithelial cells to activate a number of signaling pathways in response to exogenous estrogen stimulation. Taken together, these studies demonstrate that c-Src plays a role in ERalpha signaling in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.