ArticleOncogene2005
A new role for the oncogenic high-mobility group A2 transcription factor in myogenesis of embryonic stem cells.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Engineered uterine primary myometrial cells with high-mobility group AT-hook 2 overexpression display a leiomyoma-like transcriptional and epigenomic phenotype.F&S science · 2024Article
- Let-7e-5p Regulates IGF2BP2, and Induces Muscle Atrophy.Frontiers in endocrinology · 2021Article
- The Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2): Biochemical and Biophysical Properties, and Its Association with Adipogenesis.International journal of molecular sciences · 2020Review
- HMGA Proteins in Stemness and Differentiation of Embryonic and Adult Stem Cells.International journal of molecular sciences · 2020Review
- Skeletal Muscle Cell Induction from Pluripotent Stem Cells.Stem cells international · 2017Review
- Targeting HMGA2 in Retinoblastoma Cells in vitro Using the Aptamer Strategy.Ocular oncology and pathology · 2016Article
- Hmga2 is necessary for Otx2-dependent exit of embryonic stem cells from the pluripotent ground state.BMC biology · 2016Article
- Bidirectional Promoter Engineering for Single Cell MicroRNA Sensors in Embryonic Stem Cells.PloS one · 2016Article
- HMGA2 expression distinguishes between different types of postpubertal testicular germ cell tumour.The journal of pathology. Clinical research · 2015Article
- HMGA proteins as modulators of chromatin structure during transcriptional activation.Frontiers in cell and developmental biology · 2014Review
- Probing into the biological processes influenced by ESC factor and oncoprotein HMGA2 using iPSCs.Stem cell reviews and reports · 2013Article
- Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.Developmental cell · 2012Article
- The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells.PloS one · 2012Article
- Effects of high-mobility group a protein application on canine adipose-derived mesenchymal stem cells in vitro.Veterinary medicine international · 2012Article
- HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy.Nucleic acids research · 2009Article
- ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The CMV early enhancer/chicken beta actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors.BMC cell biology · 2008Article
- Identification of genes differentially expressed during prenatal development of skeletal muscle in two pig breeds differing in muscularity.BMC developmental biology · 2007Article
- HMG chromosomal proteins in development and disease.Trends in cell biology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high mobility group type A-2 (HMGA 2) transcription factor is involved in proliferation and differentiation, mainly during embryogenesis. Its activated form (HMGA 2/T) presents oncogenic activities both in vivo and in vitro. However, its precise role during embryogenesis is unknown. We investigated its role during the commitment of mouse embryonic stem (ES) cells by constructing cell lines expressing either wild type (wt) or HMGA 2/T forms of the gene. Following differentiation, control and wt HMGA 2 ES cells did not display myotubes; whereas HMGA 2/T ES cell lines massively formed contractile myotubes. Furthermore, as opposed to control cells, HMGA 2/T ES cells highly expressed the muscle myosin heavy chain (MHC) marker. Interestingly, in experimental conditions inhibitory for myogenesis, we observed a strong expression of MyoD and myogenin in HMGA 2/T cells. By contrast, commitment into adipocyte, neuron, and cardiomyocyte lineages was not affected. Teratocarcinomas induced by HMGA 2/T ES cell lines presented numerous skeletal muscle-differentiated tissues that were not observed in wt HMGA 2 or control tumours. Finally, rapamycin, an inhibitor of the mTOR kinase, downregulated endogenous HMGA-2 expression and inhibited myogenesis. This effect was prevented by overexpression of exogenous HMGA-2. Our results reveal a novel function of HMGA-2 in skeletal muscle differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.