ArticleOncogene2005
High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- DNA fragmentation factor 40-based therapeutic approaches for cancer: a review article.Medical oncology (Northwood, London, England) · 2024Review
- Evolution of Repetitive Elements, Their Roles in Homeostasis and Human Disease, and Potential Therapeutic Applications.Biomolecules · 2024Review
- Transposable Elements and Human Diseases: Mechanisms and Implication in the Response to Environmental Pollutants.International journal of molecular sciences · 2022Review
- Mobile element insertions and associated structural variants in longitudinal breast cancer samples.Scientific reports · 2021Article
- Transposable Elements in Human Cancer: Causes and Consequences of Deregulation.International journal of molecular sciences · 2017Review
- Sensitization of breast cancer cells to doxorubicin via stable cell line generation and overexpression of DFF40.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2015Article
- The contribution of alu elements to mutagenic DNA double-strand break repair.PLoS genetics · 2015Article
- Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo.PLoS genetics · 2015Article
- Stable overexpression of DNA fragmentation factor in T-47D cells: sensitization of breast cancer cells to apoptosis in response to acetazolamide and sulfabenzamide.Molecular biology reports · 2014Article
- Regulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night.Nucleic acids research · 2014Article
- siRNA-mediated knock-down of DFF45 amplifies doxorubicin therapeutic effects in breast cancer cells.Cellular oncology (Dordrecht, Netherlands) · 2013Article
- Inferring the expression variability of human transposable element-derived exons by linear model analysis of deep RNA sequencing data.BMC genomics · 2013Article
- Alu distribution and mutation types of cancer genes.BMC genomics · 2011Article
- All y'all need to know 'bout retroelements in cancer.Seminars in cancer biology · 2010Review
- A mobile threat to genome stability: The impact of non-LTR retrotransposons upon the human genome.Seminars in cancer biology · 2010Review
- Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.Cancer genetics and cytogenetics · 2010Article
- Genomic deletion within GLDC is a major cause of non-ketotic hyperglycinaemia.Journal of medical genetics · 2007Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Alu repetitive elements, which constitute 10% of human genome, may serve as bridges for genomic recombination. However, their roles in tumorigenesis remain to be elucidated. Caspase-activated DNase (CAD), whose gene (hCAD) is mapped at chromosome 1p36, a region frequently displaying hemizygote deletion in many human cancers, is the key enzyme for nucleosome fragmentation during apoptosis. Recently, we detected many aberrant mRNAs for hCAD in many human hepatoma cells. To elucidate the genetic basis leading to the mRNA aberration, we used PCR-based chromosome walking to clone the corresponding genomic DNA identifying a novel Alu/Alu homologous recombination/deletion within hCAD in HepG2 and Hep3B cells. We then detected similar recombination events in 13 out of the 20 hepatoma tissues and in eight of the para-cancerous cirrhotic livers. The recombination was inclined to occur in males (P=0.031) and had marginal association with high-grade hepatoma (P=0.070) and tumor recurrence (P=0.070). The recombination caused exon-3 deletion, which in turn led to exon-3 skipping or replacement with a partial Alu-sequence, and consequential C-truncation of CAD. Our findings of high frequency of Alu-mediated hCAD deletion in human hepatoma not only underscore the implication of hCAD in hepatocarcinogenesis, but also highlight the potential roles of human repetitive sequences in mediating genome instability in human cancers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.