ArticleOncogene2005
Retinoblastoma protein acts as Pax 8 transcriptional coactivator.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Mechanistic Insights of Thyroid Cancer Progression.Endocrinology · 2023Review
- Understanding Retinoblastoma Post-Translational Regulation for the Design of Targeted Cancer Therapies.Cancers · 2022Review
- Deacetylase activity-independent transcriptional activation by HDAC2 during TPA-induced HL-60 cell differentiation.PloS one · 2018Article
- Polymorphism in lncRNA AC016683.6 and its interaction with smoking exposure on the susceptibility of lung cancer.Cancer cell international · 2018Article
- The RB tumor suppressor at the intersection of proliferation and immunity: relevance to disease immune evasion and immunotherapy.Cell cycle (Georgetown, Tex.) · 2015Review
- PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein.Oncogene · 2011Article
- Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma.Immunology · 2011Article
- RB1, development, and cancer.Current topics in developmental biology · 2011Review
- PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription.Laboratory investigation; a journal of technical methods and pathology · 2009Article
- Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease.Pigment cell & melanoma research · 2008Review
- Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?Cell division · 2007Article
- Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells.Molecular cancer · 2006Article
- Review
- Review
- An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.Molecular and cellular biology · 2006Article
- Rb1 mRNA expression in developing mouse teeth.Gene expression patterns : GEPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control of cell proliferation and differentiation by the retinoblastoma protein (pRb) depends on its interactions with key cellular substrates. Available data indicate that pRb and the transcription factor Pax 8 play a crucial role in the differentiation of thyroid follicular cells. In this study, we show that pRb takes part in the complex assembled on the thyroperoxidase gene promoter acting as a transcriptional coactivator of Pax 8. Accordingly, pRb interacts with and potentiates Pax 8 transcriptional activity. In addition, we show that the downregulation of pRb gene expression, in thyrocytes, through RNA interference results in a reduction of the thyroperoxidase gene promoter activity mediated by the Pax 8-binding site. In agreement with these results and with the ability of the adenoviral protein E1A to bind pRb, we show that E1A downregulates Pax 8 activity and that such inhibition requires the E1A-Rb interaction. Furthermore, we show that the Pax 8/pRb synergy plays a role on the sodium/iodide symporter gene expression as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.