ArticleBiophysical journal2005
Lamellipodial contractions during crawling and spreading.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
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- Tissue Augmentation in Wound Healing: the Role of Endothelial and Epithelial Cells.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Review
- Cell protrusion and retraction driven by fluctuations in actin polymerization: A two-dimensional model.Cytoskeleton (Hoboken, N.J.) · 2017Article
- Amoebae as Mechanosensitive Tanks.Biophysical journal · 2017Article
- Mechanosensitive Adhesion Explains Stepping Motility in Amoeboid Cells.Biophysical journal · 2017Article
- Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge.Physical biology · 2015Article
- New single-molecule speckle microscopy reveals modification of the retrograde actin flow by focal adhesions at nanometer scales.Molecular biology of the cell · 2014Article
- Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility.Molecular biology of the cell · 2013Article
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
- Effects of adhesion dynamics and substrate compliance on the shape and motility of crawling cells.PloS one · 2013Article
- Physical model for self-organization of actin cytoskeleton and adhesion complexes at the cell front.Biophysical journal · 2012Article
- Excitable actin dynamics in lamellipodial protrusion and retraction.Biophysical journal · 2012Article
- The Moving Boundary Node Method: A level set-based, finite volume algorithm with applications to cell motility.Journal of computational physics · 2010Article
- Calcium participates in feedback regulation of the oscillating ROP1 Rho GTPase in pollen tubes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Mathematics of cell motility: have we got its number?Journal of mathematical biology · 2009Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Most eukaryotic cells can crawl over surfaces. In general, this motility requires three distinct actions: polymerization at the leading edge, adhesion to the substrate, and retraction at the rear. Recent experiments with mouse embryonic fibroblasts showed that during spreading and crawling the lamellipodium undergoes periodic contractions that are substrate-dependent. Here I show that a simple model incorporating stick-slip adhesion and a simplified mechanism for the generation of contractile forces is sufficient to explain periodic lamellipodial contractions. This model also explains why treatment of cells with latrunculin modifies the period of these contractions. In addition, by coupling a diffusing chemical species that can bind actin, such as myosin light-chain kinase, with the contractile model leads to periodic rows and waves in the chemical species, similar to what is observed in experiments. This model provides a novel and simple explanation for the generation of contractile waves during cell spreading and crawling that is only dependent on stick-slip adhesion and the generation of contractile force and suggests new experiments to test this mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.