ArticleProceedings of the National Academy of Sciences of the United States of America2005
Synaptic mechanisms of persistent reverberatory activity in neuronal networks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70 citing papers in PubMed.
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- Calcium-Dependent Hyperexcitability in Human Stem Cell-Derived Rett Syndrome Neuronal Networks.Biological psychiatry global open science · 2024Article
- Secretagogin regulates asynchronous and spontaneous glutamate release in hippocampal neurons through interaction with Doc2α.Life medicine · 2023Article
- Quantum computing architectures with signaling and control mimicking biological processes.Heliyon · 2023Article
- Conserved Spatiotemporal Dynamics with Millisecond Precision During Reverberatory Activity in a Self-organized Neuronal Network.Neuroscience bulletin · 2023Article
- Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal Networks.Neuroscience bulletin · 2023Article
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- Spatial information transfer in hippocampal place cells depends on trial-to-trial variability, symmetry of place-field firing, and biophysical heterogeneities.Neural networks : the official journal of the International Neural Network Society · 2021Article
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- A magnetically actuated microrobot for targeted neural cell delivery and selective connection of neural networks.Science advances · 2020Article
- Post-stimulatory activity in primate auditory cortex evoked by sensory stimulation during passive listening.Scientific reports · 2020Article
- Astrocytic Regulation of Synchronous Bursting in Cortical Cultures: From Local to Global.Cerebral cortex communications · 2020Article
- Bayesian inference of neuronal assemblies.PLoS computational biology · 2019Article
- Excitation wavelength optimization improves photostability of ASAP-family GEVIs.Molecular brain · 2018Article
- Propagation and synchronization of reverberatory bursts in developing cultured networks.Journal of computational neuroscience · 2017Article
10 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
For brain functions such as working memory and motor planning, neuronal circuits are able to sustain persistent activity after transient inputs. Theoretical studies have suggested that persistent activity can exist in recurrently connected networks as active reverberation. However, the actual cellular processes underlying such reverberation are not well understood. In this study, we investigated the basic synaptic mechanisms responsible for reverberatory activity in small networks of rat hippocampal neurons in vitro. We found that brief stimulation of one neuron in a network could evoke, in an all-or-none fashion, reverberatory activity lasting for seconds. The reverberation was likely to arise from recurrent excitation because it was eliminated by partial inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors (but not by blockade of NMDA receptors). In contrast, blocking inhibitory transmission with bicuculline enhanced the reverberation. Furthermore, paired-pulse stimuli with interpulse intervals of 200-400 ms were more effective than single pulses in triggering reverberation, apparently by eliciting higher levels of asynchronous transmitter release. Suppressing asynchronous release by EGTA-AM abolished reverberation, whereas elevating asynchronous release by strontium substantially enhanced reverberation. Finally, manipulating calcium uptake into or release from intracellular stores also modulated the level of reverberation. Thus, the oft-overlooked asynchronous phase of synaptic transmission plays a central role in the emergent phenomenon of network reverberation.
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